PMID: 39901Sep 1, 1978

Oxidative deamination of thialysine by snake venom L-aminoacid oxidase

The Italian Journal of Biochemistry
C CiniC De Marco


Thialysine is oxidatively deaminated by snake venom L-aminoacid oxidase at alkaline pH. The oxygen consumption curves show a characteristic diphasic course: the quick uptake of half a mole of oxygen per mole of substrate, in aggreement with a typical oxidative deamination, is followed by a slow extra oxygen consumption. The first product of the reaction is the corresponding alpha-oxo-epsilon-amino acid, which spontaneously cyclizes to the internal Schiff base 5-6-dihydro-delta 3,1,4-thiazin-3-carboxylic acid (TZCA). This latter has been identified by its UV absorption spectrum, by some chemical reactions, by paper chromatography, and by the production of cystamine and glyoxylic acid after prolonged oxidation of thialysine followed by acid hydrolysis. The possibility of an alpha-beta elimination reaction giving rise to cysteamine from thialysine, coupled to the oxidative deamination, has been excluded.

Related Concepts

Amino Acid Oxidoreductases
Amino Acids, Sulfur
Paper Chromatography (Procedure)
Hydrogen-Ion Concentration
Lysine Hydrochloride
Snake Venoms
Spectrophotometry, Ultraviolet

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