PMID: 671251Aug 1, 1978Paper

Oxidative degradation of pharmaceutically important phenothiazines I: Isolation and identification of oxidation products of promethazine

Journal of Pharmaceutical Sciences
W J Underberg

Abstract

The thermal degradation of promethazine in water in the presence of oxygen was studied. After degradation, the products were isolated by TLC. Identification was carried out by comparison of the isolated compounds with reference compounds. Melting points, spectral data, and polarographic and chromatographic behavior were compared. The following products were identified: 10-methylphenothiazine, phenothiazine, 3H-phenothiazine-3-one, phenothiazine 5-oxide, promethazine 5-oxide, 7-hydroxy-3H-phenothiazine-3-one, acetaldehyde, formaldehyde, and dimethylamine.

Citations

May 16, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zuzana BosákováEva Tesarová
Jun 21, 1985·Pharmaceutisch Weekblad. Scientific Edition·N J De Mol, J Koenen
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Feb 26, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Cécile BizeMuriel Blanzat
Jan 1, 1983·Contact Dermatitis·M Bruze, S Fregert
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Jan 1, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Martin LitzenburgerRita Bernhardt

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