Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease

American Journal of Physiology. Gastrointestinal and Liver Physiology
Daqing GaoAnna Mae Diehl

Abstract

Mitochondrial generation of reactive oxygen species (ROS) is increased in mice with fatty livers induced by genetic obesity, chronic consumption of ethanol, or methionine/choline-deficient diets. Both nuclear and mitochondrial (mt) DNA are targets for ROS-induced damage and accumulate hydroxylated bases, such as 8-hydroxy-2'-deoxyguanosine (8-oxoG) and base substitution of adenine with 8-oxoG (A*8-oxoG), that introduce mutations that promote cancer as well as cell death. The mammalian homolog of the bacterial DNA mismatch repair enzyme MutY (MYH) removes A*8-oxoG from nuclear and mtDNA, reduces 8-oxoG accumulation, and restores genomic stability after ROS exposure. Cumulative damage to mtDNA occurs as fatty liver disease progresses. Therefore, differences in hepatic MYH activity may influence the severity of fatty liver disease. To evaluate this hypothesis, we compared mtH2O2 production, MYH expression, oxidative DNA damage, and hepatocyte death in healthy mice and different mouse models of fatty liver disease. The results show that diverse causes of steatohepatitis increase mtROS production, limit repair of mtDNA, and oxidatively damage DNA. However, there are important differences in the DNA repair response to oxidant stress ...Continue Reading

References

Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C RichterB N Ames
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Oct 1, 1994·Alcoholism, Clinical and Experimental Research·D M WilsonM R Kelley
Apr 1, 1994·Circulation·C M WeiJ C Burnett
Nov 1, 1993·Carcinogenesis·J HeglerB Epe
Sep 1, 1993·Circulation·C M WeiJ C Burnett
May 15, 1996·The Journal of Clinical Investigation·M JougasakiJ C Burnett
Aug 1, 1997·Gastroenterology·A MansouriD Pessayre
Mar 11, 1998·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Y KaneshiroM Yamaguchi
Apr 18, 1998·Gastroenterology·C P Day, O F James
Mar 31, 1999·Free Radical Research·E K HudsonR G Hansford
Jun 22, 2000·Archives of Biochemistry and Biophysics·S YangA M Diehl
Apr 12, 2001·Seminars in Liver Disease·S Chitturi, G C Farrell
Apr 12, 2001·Seminars in Liver Disease·E S Siegelman, M A Rosen
Aug 29, 2001·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·P NavasumritP J O'Connor
Nov 20, 2001·Nucleic Acids Research·J SelfridgeD W Melton
Feb 6, 2002·Free Radical Biology & Medicine·Hagir B SulimanClaude A Piantadosi
Apr 12, 2002·Gene·Vilhelm A BohrNadja C de Souza-Pinto
Jun 13, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria L Martínez-ChantarShelly C Lu
Aug 20, 2002·Current Genetics·Dongchon Kang, Naotaka Hamasaki
Dec 14, 2002·American Journal of Respiratory and Critical Care Medicine·Hagir B SulimanClaude A Piantadosi
Feb 28, 2003·The New England Journal of Medicine·Oliver M SieberIan P M Tomlinson
Mar 29, 2003·Journal of Vascular Surgery·Ruxian LinChiming Wei
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard M Green
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Bartosz SzczesnyIstvan Boldogh
Sep 11, 2003·The Journal of Biological Chemistry·Antony R ParkerJames R Eshleman
Nov 18, 2003·Cellular and Molecular Life Sciences : CMLS·A R Parker, J R Eshleman
Nov 26, 2003·Mutation Research·P FortiniE Dogliotti
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shiqi YangAnna Mae Diehl

❮ Previous
Next ❯

Citations

May 15, 2012·Molecular and Cellular Endocrinology·E Matthew MorrisR Scott Rector
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Vladimir VartanianR Stephen Lloyd
Oct 26, 2010·Antioxidants & Redox Signaling·Roberto GambinoMaurizio Cassader
Dec 7, 2010·Antioxidants & Redox Signaling·E Matthew MorrisJamal A Ibdah
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Dominique Pessayre
Feb 18, 2009·The Journal of Clinical Investigation·Zhongsheng PengBruce N Cronstein
Aug 7, 2013·BMC Biology·Inmaculada García-RuizJosé A Solís-Herruzo
Jun 2, 2012·World Journal of Gastroenterology : WJG·Yoshihisa TakahashiToshio Fukusato
May 23, 2014·Oxidative Medicine and Cellular Longevity·Otto KučeraZuzana Cervinková
Nov 26, 2008·Virchows Archiv : an International Journal of Pathology·Rachel S van der PostNicoline Hoogerbrugge
May 8, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jesse D Riordan, Joseph H Nadeau
Nov 15, 2014·Current Pathobiology Reports·Allyson K MartínezShannon S Glaser
Jun 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hak Sung LeeYeong Shik Kim
Mar 15, 2016·Metabolism: Clinical and Experimental·Naim Alkhouri, Ariel E Feldstein
Jun 22, 2007·Psychiatry Research·Ana Cristina AndreazzaFlavio Kapczinski
Jun 5, 2007·Clinics in Liver Disease·Roslyn M London, Jacob George
Jan 27, 2006·International Journal of Experimental Pathology·Quentin M Anstee, Robert D Goldin
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marie-Anne RobinBernard Fromenty
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mitsuteru KitadeHiroshi Fukui
Apr 4, 2007·Alcoholism, Clinical and Experimental Research·Katherine A RadekLuisa A DiPietro
Jan 10, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elena BellafanteAntonio Moschetta
Feb 19, 2015·Journal of Applied Toxicology : JAT·Shota TakumiKeiko Nohara
Mar 14, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Zoon TariqLeanne Hodson
Jun 20, 2006·Journal of Hepatology·Ayako SuzukiAnna Mae Diehl
Jan 13, 2006·Mitochondrion·Karima BegricheBernard Fromenty
Apr 13, 2005·Gastroenterology Clinics of North America·Anna Mae Diehl
Nov 5, 2014·Free Radical Research·J-H ZhangL-L Zhu
Feb 4, 2012·Free Radical Research·Harini SampathR Stephen Lloyd
May 21, 2016·Frontiers in Pharmacology·Nabil EidYoshinori Otsuki
Mar 17, 2016·Annual Review of Pathology·Timothy HardyChristopher P Day
Aug 16, 2016·Cellular and Molecular Life Sciences : CMLS·Simon DucheixAntonio Moschetta
Aug 16, 2016·Acta Medica (Hradec Králové)·Tomáš GarnolZuzana Červinková
Jun 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna WieckowskaAriel E Feldstein
Jan 1, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yan LiuSteven Dooley
Jul 1, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Waleska Dornas, Detlef Schuppan
Apr 12, 2011·Expert Review of Gastroenterology & Hepatology·Venessa PattulloJacob George

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Mercedes Pérez-CarrerasJosé A Solis-Herruzo
Diabetes & Metabolism
Bernard FromentyDominique Pessayre
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Ariel E FeldsteinGregory J Gores
© 2022 Meta ULC. All rights reserved