Oxidative effects on lung inflammatory response in rats exposed to different concentrations of formaldehyde

Environmental Pollution
Giselle Luciane MurtaFrank Silva Bezerra

Abstract

The formaldehyde (FA) is a crosslinking agent that reacts with cellular macromolecules such as proteins, nucleic acids and molecules with low molecular weight such as amino acids, and it has been linked to inflammatory processes and oxidative stress. This study aimed to analyze the oxidative effects on pulmonary inflammatory response in Fischer rats exposed to different concentrations of FA. Twenty-eight Fischer rats were divided into 4 groups (N = 7). The control group (CG) was exposed to ambient air and three groups were exposed to different concentrations of FA: 1% (FA1%), 5% (FA5%) and 10% (FA10%). In the Bronchoalveolar Lavage Fluid (BALF), the exposure to a concentration of 10% promoted the increase of inflammatory cells compared to CG. There was also an increase of macrophages and lymphocytes in FA10% and lymphocytes in FA5% compared to CG. The activity of NADPH oxidase in the blood had been higher in FA5% and FA10% compared to CG. The activity of superoxide dismutase enzyme (SOD) had an increase in FA5% and the activity of the catalase enzyme (CAT) showed an increase in FA1% compared to CG. As for the glutathione system, there was an increase in total glutathione (tGSH), reduced glutathione (GSH) and oxidized glutathion...Continue Reading

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Citations

May 10, 2017·Journal of Occupational and Environmental Medicine·Ritsuko Arakawa SuzukiHajime Kurosawa
Oct 27, 2018·Toxicology and Industrial Health·Qiu-Ping LiuShi-Jie Wang
Feb 19, 2020·Experimental Lung Research·Erika Tiemi KozimaFrank Silva Bezerra
Jul 10, 2020·Experimental Biology and Medicine·Andréa Cristiane Lopes da SilvaFrank Silva Bezerra
Jul 21, 2020·Drug and Chemical Toxicology·Letícia BernardiniNatália Brucker
Nov 18, 2020·Respiratory Physiology & Neurobiology·Matheus Rocha AlmeidaFrank Silva Bezerra
Aug 20, 2019·Chemical Research in Toxicology·Ana K Gutiérrez-GarcíaAntonio De Leon-Rodriguez
Jun 26, 2020·Ecotoxicology and Environmental Safety·Zhaohui XueXiaohong Kou
Nov 10, 2021·Inhalation Toxicology·Qiu-Ping LiuDang-Xia Zhou

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