Oxidative imbalance and kidney damage in spontaneously hypertensive rats: activation of extrinsic apoptotic pathways

Clinical Science
D La RussaD Pellegrino

Abstract

In both humans and animals, essential hypertension acts as a risk factor for subclinical kidney damage and precedes renal dysfunction. Several lines of evidence indicate that hypertension and oxidative stress are closely related. The increase in vascular oxidative stress plays a key role in the pathophysiological consequences of hypertension, including kidney disease. Our study examined this issue in spontaneously hypertensive rat (SHR), a reliable model of essential hypertension. We used SHR 20 weeks old when hypertension is stably developed, vascular remodeling started, but kidney function is preserved. We examined plasmatic pro-oxidant and antioxidant status showing a significant alteration in oxidative balance in SHR. As index of oxidative damage, we evaluated lipid peroxidation in kidney, liver, and skeletal muscle, detecting a significant rise in lipid peroxidation levels in all SHR tissues, particularly relevant in kidney. In addition, we analyzed the expression of cytoplasmic antioxidant enzymes, superoxide dismutase 1 (SOD1) and glutatione S-tranferasi P1 (GSTP1). In SHR liver, SOD1 expression slight increased while we have not detected any variation in other tissues. Concerning GSTP1, SHR renal tissues did not display...Continue Reading

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Citations

Jan 12, 2019·Annual Review of Public Health·Lawrence A PalinkasAlison B Hamilton
Feb 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Trevor Tapiwa NyakudyaKennedy Honey Erlwanger
May 16, 2019·International Journal of Environmental Research and Public Health·Ying ShaoLingling Wu
May 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yi Shan HuangYu Ning Liu
Mar 20, 2019·Oxidative Medicine and Cellular Longevity·Daniele La RussaRenzo Bonofiglio
Jul 7, 2020·Disease Markers·Cao FangYingzhong Lin
Aug 25, 2019·Nutrients·Stefanos RoumeliotisVassilios Liakopoulos
Feb 10, 2021·Journal of Cellular Physiology·Alessia RemiganteAngela Marino
Mar 23, 2021·The Journal of Pharmacy and Pharmacology·Daniele La RussaDiana Amantea

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