Oxidative injuries induced by maternal low-protein diet in female brainstem

Nutritional Neuroscience
Shirley Maria de SousaClaudia Lagranha

Abstract

Many studies have shown that a maternal low-protein diet increases the susceptibility of offspring to cardiovascular disease in later-life. Moreover, a lower incidence of cardiovascular disease in females than in males is understood to be largely due to the protective effect of high levels of estrogens throughout a woman's reproductive life. However, to our knowledge, the role of estradiol in moderating the later-life susceptibility of offspring of nutrient-deprived mothers to cardiovascular disease is not fully understood. The present study is aimed at investigating whether oxidative stress in the brainstem caused by a maternal low-protein diet administered during a critical period of fetal/neonatal brain development (i.e during gestation and lactation) is affected by estradiol levels. Female Wistar rat offspring were divided into four groups according to their mothers' diets and to the serum estradiol levels of the offspring at the time of testing: (1) 22 days of age/control diet: (2) 22 days of age/low-protein diet; (3) 122 days of age/control diet: (4) 122 days of age/low-protein diet. Undernutrition in the context of low serum estradiol compared to undernutrition in a higher estradiol context resulted in increased levels o...Continue Reading

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Citations

Nov 23, 2017·Clinical and Experimental Pharmacology & Physiology·José Luiz de Brito Alves, João Henrique Costa-Silva
May 29, 2018·The European Journal of Neuroscience·Tercya Lucidi Araujo SilvaClaudia Jacques Lagranha
Sep 8, 2017·Frontiers in Pediatrics·Flavia IndrioGiuseppe Loverro
Feb 26, 2021·Nature Reviews. Nephrology·Wakako Kawarazaki, Toshiro Fujita

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