Jan 1, 1975

Oxidative metabolism of funicular tissue. II. Determination of the activity of certain Krebs cycle enzymes

Comptes rendus des séances de la Société de biologie et de ses filiales
E Brachet

Abstract

Previous experiments have suggested that a partial metabolic block might restrain the oxidative metabolism of the cord tissue between the decarboxylation of pyruvate and the oxidation of succinate. Some of the dehydrogenases of the Kreb's cycle were assayed on acetone powders prepared from human cords. Isocitrate dehydrogenases (both NAD and NADP-specific) have much lower activities than the alpha-ketoglutarate- and malate dehydrogenases; a partial block might be located at this level. Moreover, the malic enzyme has a rather high activity, and might play a significant role by regenerating NADPH in a tissue where other sources of this coenzyme are practically absent.

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Mentioned in this Paper

Metabolic Process, Cellular
Enzymes, antithrombotic
Malate dehydrogenase (decarboxylating)
Malate Dehydrogenase
Isocitrate
Alpha Ketoglutarate
Pyruvate Measurement
Succinates
Cell Respiration
Acetone Measurement

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