Oxidative metabolism of limbic structures after acute administration of diazepam, alprazolam and zolpidem

Progress in Neuro-psychopharmacology & Biological Psychiatry
Héctor González-PardoJ L Arias

Abstract

The effects of acute administration of two benzodiazepines and a non-benzodiazepine hypnotic on behavior and brain metabolism were evaluated in rats. After testing the behavioral action of the benzodiazepines on the open field and the elevated plus-maze, the effects of the three drugs on neuronal metabolism of particular limbic regions were measured using cytochrome c oxidase (CO) histochemistry. Diazepam (5 mg/kg i.p.) and alprazolam (0.5 mg/kg i.p.) induced clear anxiolytic effects and a decrease in locomotion, whereas zolpidem (2 mg/kg i.p.) caused an intense hypnotic effect. The anxiolytic effects of alprazolam were distinguishable from diazepam due to the pharmacological and clinical profile of this triazolobenzodiazepine. CO activity decreased significantly in almost all the limbic regions evaluated after zolpidem administration. However, significant prominent decreases in CO activity were found after diazepam treatment in the medial mammillary nucleus, anteroventral thalamus, cingulate cortex, dentate gyrus and basolateral amygdala. Alprazolam caused similar decreases in CO activity, with the exception of the prelimbic and cingulate cortices, where significant increases were detected. In agreement with previous studies u...Continue Reading

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Citations

Jun 26, 2012·Psychopharmacology·Karina A ZaninRoberto Frussa-Filho
Jul 6, 2010·Neuroscience Letters·Maurizio CasarrubeaGiuseppe Crescimanno
Mar 4, 2008·Pharmacology, Biochemistry, and Behavior·Héctor González-PardoAndrés Parra
Apr 19, 2008·European Journal of Pharmacology·Christiaan H VinkersLucianne Groenink
Jun 9, 2014·European Psychiatry : the Journal of the Association of European Psychiatrists·P PifarréJ Pujol
Dec 25, 2010·Pharmacology, Biochemistry, and Behavior·Helen M MurphyCyrilla H Wideman
Jul 8, 2008·Journal of Pharmacological Sciences·Tomomi NishinoChiaki Kamei
Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Farhan MohammadAdam Claridge-Chang
Dec 26, 2008·Journal of Biomolecular Structure & Dynamics·Biswarup SahaParimal Karmakar

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