Abstract
Macrophage-derived foam cells are hallmarks of early atherosclerotic lesions. Oxidatively modified LDL has been suggested to be a more atherogenic form than native LDL. Oxidized LDL--but not native LDL--is chemotactic to monocytes and is avidly degraded by macrophages, resulting in their conversion to foam cells. Incubation of LDL with any of several different types of cells, or with copper ion even in the absence of cells, results in the oxidative modification of LDL. While the cell and the copper systems generate oxidatively modified LDL with similar properties, the two systems differ in their sensitivity to inhibition by superoxide dismutase and by several lipoxygenase inhibitors. In cultured endothelial cells, inhibitors of lipoxygenase, some of them without non-specific antioxidant activity, inhibited cell-mediated modification by 50-80%. In contrast, superoxide dismutase inhibited the process by 20% or less. Moreover, we have shown that soybean lipoxygenase in a cell-free system can modify LDL directly to a form recognized and degraded specifically and rapidly by macrophages. Lipoxygenase-modified LDL is also chemotactic for human monocytes and is cleared rapidly from the circulation, properties shared by cell- or copper-...Continue Reading
Citations
Apr 30, 2008·Rheumatology International·Yaniv ShererYehuda Shoenfeld
Aug 1, 1992·The International Journal of Biochemistry·M Kongshaug
Feb 1, 1993·Atherosclerosis·W JessupR T Dean
Jan 1, 1991·Free Radical Biology & Medicine·D R Janero
Jan 1, 1992·Free Radical Biology & Medicine·S BradamanteC Vergani
Feb 12, 2008·The Journal of Biological Chemistry·Richard HarkewiczYury I Miller
Jan 28, 2009·Current Rheumatology Reports·Eiji MatsuuraLuis R Lopez
Jan 1, 2016·Biochimie·R SalvayreC Camaré
Aug 2, 2006·Rheumatic Diseases Clinics of North America·Eiji MatsuuraLuis R Lopez
May 1, 1997·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R J KarmanC M Hart
Mar 7, 2002·Neurological Research·Tom ThomasPrem Thomas
Jul 5, 2005·Expert Opinion on Investigational Drugs·P Holvoet
Jan 10, 2012·Chemistry and Physics of Lipids·Ivana MilicRalf Hoffmann
Jan 1, 1992·Progress in Lipid Research·S Parthasarathy, S M Rankin
Apr 1, 1996·Critical Reviews in Food Science and Nutrition·I Jialal, C J Fuller
Mar 31, 2009·Journal of Hypertension·Takahiro UenoTatsuya Sawamura
Aug 11, 2006·Lupus·E MatsuuraL R Lopez
Oct 2, 2008·Lupus·E Matsuura, L R Lopez
Jan 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K A LindstedtP T Kovanen
Apr 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·C BergmarkJ Swedenborg
Nov 23, 2005·Circulation·Yehuda ShoenfeldYaniv Sherer
Apr 1, 1997·Basic Research in Cardiology·C NapoliG Ambrosio
Jul 29, 2019·Atherosclerosis·Arun SurendranAmir Ravandi
Sep 18, 2002·Journal of Lipid Research·Qingping LiuEiji Matsuura
Apr 14, 1994·Biochimica Et Biophysica Acta·E L ManderW Jessup
Jan 14, 2004·Journal of Vascular Surgery·John A van AalstLinda M Graham