PMID: 11342239May 9, 2001Paper

Oxidative mutagenesis of doxorubicin-Fe(III) complex

Mutation Research
E L Kostoryz, D M Yourtee

Abstract

Doxorubicin has a high affinity for inorganic iron, Fe(III), and has potential to form doxorubicin-Fe(III) complexes in biological systems. Indirect involvement of iron has been substantiated in the oxidative mutagenicity of doxorubicin. In this study, however, direct involvement of Fe(III) was evaluated in mutagenicity studies with the doxorubicin-Fe(III) complex. The Salmonella mutagenicity assay with strain TA102 was used with a pre-incubation step. The highest mutagenicity of doxorubicin-Fe(III) complex was observed at the dose of 2.5nmol/plate of the complex. The S9-mix decreased this highest mutagenicity but increased the number of revertants at a higher dose of 10nmol/plate of the complex. On the other hand, the mutagenicity of the doxorubicin-Fe(III) complex at the doses of 0.25, 0.5, 1 and 2nmol/plate was enhanced about twice by the addition of glutathione plus H(2)O(2). This enhanced mutagenicity as well as of the complex itself, the complex plus glutathione, and the complex plus H(2)O(2) were reduced by the addition of ADR-529, an Fe(III) chelator, and potassium iodide, a hydroxyl radical scavenger. These results indicate that doxorubicin-Fe(III) complex exert the mutagenicity through oxidative DNA damage and that Fe...Continue Reading

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Citations

Oct 31, 2008·Talanta·A M Oliveira-BrettJ A P Piedade
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·Bernd HutterHannes Loferer
Sep 1, 2015·Analytica Chimica Acta·Ali A EnsafiElham Aghaee
Jan 4, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P D L LimaR R Burbano
Feb 2, 2015·Journal of Hazardous Materials·Alfredo ParrellaMarina Isidori
Aug 5, 2006·Biochimica Et Biophysica Acta·Andreas FritzeRegine Peschka-Süss
Aug 27, 2003·Medicinal Research Reviews·Li-June Ming
Jun 27, 2003·American Journal of Hematology·Timothy B Chaston, Des R Richardson
May 23, 2003·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Timothy B Chaston, Des R Richardson
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Timothy B ChastonDes R Richardson

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