Oxidative phosphorylation efficiency, proton conductance and reactive oxygen species production of liver mitochondria correlates with body mass in frogs

The Journal of Experimental Biology
Damien RousselYann Voituron

Abstract

Body size is a central biological parameter affecting most biological processes (especially energetics) and the mitochondrion is a key organelle controlling metabolism and is also the cell's main source of chemical energy. However, the link between body size and mitochondrial function is still unclear, especially in ectotherms. In this study, we investigated several parameters of mitochondrial bioenergetics in the liver of three closely related species of frog (the common frog Rana temporaria, the marsh frog Pelophylax ridibundus and the bull frog Lithobates catesbeiana). These particular species were chosen because of their differences in adult body mass. We found that mitochondrial coupling efficiency was markedly increased with animal size, which led to a higher ATP production (+70%) in the larger frogs (L. catesbeiana) compared with the smaller frogs (R. temporaria). This was essentially driven by a strong negative dependence of mitochondrial proton conductance on body mass. Liver mitochondria from the larger frogs (L. catesbeiana) displayed 50% of the proton conductance of mitochondria from the smaller frogs (R. temporaria). Contrary to our prediction, the low mitochondrial proton conductance measured in L. catesbeiana was...Continue Reading

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Citations

Sep 26, 2019·Proceedings. Biological Sciences·Boël MélanieRoussel Damien
Jun 18, 2020·Proceedings. Biological Sciences·Stefania CasagrandeScott R McWilliams
Jun 13, 2020·The Journal of Experimental Biology·Alexey SukhotinInna M Sokolova
Jun 12, 2020·Biological Reviews of the Cambridge Philosophical Society·Jan KozłowskiMarcin Czarnoleski
Jun 9, 2020·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Noel R ParkWendy R Hood
Jul 22, 2018·Environmental Science and Pollution Research International·Mathilde PigneretFrédéric Hervant
Aug 2, 2020·Mitochondrion·Yann VoituronDamien Roussel
Jun 21, 2019·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Loïc TeulierClaire Saraux

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