PMID: 3727476May 1, 1986Paper

Oxidative phosphorylation, NADH-oxidase and succinate oxidase activity in testicular mitochondria of rats with alloxan diabetes

Voprosy medit︠s︡inskoĭ khimii
A M TaryshkinE V Dolgikh

Abstract

Decrease in V4P, V3 and VP, in coefficient of respiratory control, in the ratio ADP:0 as well as an increase in duration of phosphorylation of ADP involved in oxidation of succinate were found in testes mitochondria from rats with alloxan diabetes (content of glucose 20 +/- 2 mmol/L in blood plasma). If a mixture of malate and glutamate was used as a substrate of oxidation, the rate of mitochondrial respiration and coefficient of respiratory control were decreased in testes of diabetic rats under conditions of all the metabolic states studied. At the same time, sensitivity of NADH-oxidase and succinate oxidase systems to controlled heating (28 degrees) was distinctly decreased in the testes mitochondrial membranes of the impaired animals as compared with controls. The data obtained suggest that distinct functional and, apparently, structure alterations occurred in the testes mitochondrial membranes of rats with alloxan diabetes.

Related Concepts

Succinate oxidase
NADH2 oxidase
Streptozotocin Diabetes
Mitochondria
Multienzyme Complexes
NADH, NADPH Oxidoreductases
Oxidative Phosphorylation
Oxidase
Oxygen Consumption
Testis

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