Oxidative profiles of LDL and HDL isolated from women with preeclampsia

Lipids in Health and Disease
G León-ReyesY D Torres-Ramos

Abstract

Oxidative stress causes biochemical changes in lipids and proteins; these changes can induce damage to the vascular endothelium and create maternal complications that are characteristic of preeclampsia. In this study, we evaluated the oxidative profile of lipoproteins isolated from women with preeclampsia. Thirty women diagnosed with preeclampsia and thirty women without preeclampsia were included in the study. Lipid-damage biomarkers, including conjugated dienes, lipohydroperoxides and malondialdehyde, were measured. The reduction of nitroblue tetrazolium, the formation of dityrosines, and the carbonylation of proteins were assessed as indicators of protein damage. The protective activity of HDL-c was evaluated by the paraoxonase-I activity present on the HDL-c particles. Serum lipid profiles were also quantified in both groups. Data were analysed using Student's t test and the Pearson correlation coefficient. Our results demonstrated in PE women evident oxidative changes in the lipids and proteins in HDL-c and LDL-c particles and the activity of the antioxidant enzyme PON-I decreased 59.9%. HDL-c exhibited self-defence, as demonstrated by the negative correlation between paraoxonase-I activity and the formation of lipohydrope...Continue Reading

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Citations

May 12, 2018·Lipids in Health and Disease·G León-ReyesY D Torres-Ramos
Jul 26, 2019·The Journal of Physiology·Wilfried Gyselaers, Basky Thilaganathan
Feb 1, 2019·The Cerebellum·Karla Tercero-PérezJonathan J Magaña
Jul 16, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Elena KonradAmr A Soliman

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