PMID: 8972731Nov 8, 1996Paper

Oxidative signalling and gene expression during lymphocyte activation

Biochimica Et Biophysica Acta
S D GoldstoneN H Hunt

Abstract

We previously have demonstrated an obligatory requirement for intracellular reactive oxygen species (ROS) generation during T lymphocyte activation, and have proposed that ROS may act as signalling agents in the regulation of certain cellular processes, for example, during cell cycle entry. In order to test this hypothesis, we have been interested to determine which, if any, cell cycle entry events are affected by oxidative signalling. Given the requirement for both oxidative signalling and altered gene expression during the G0 to G1 phase transition, we have attempted to establish the extent to which oxidative signalling affects global gene expression patterns during cell cycle entry, and to isolate and characterize mRNAs whose expression patterns are responsive to oxidative signalling during this process. Using differential display in a phenotypic screening approach, we have identified 10 mRNA species whose expression patterns were altered in response to inhibition of oxidative signalling during cell cycle entry. The expression patterns of 4 of these 10 mRNAs were unaffected during cell cycle arrest caused by a different mechanism, cyclosporin A-induced interference with calcineurin-mediated signalling events, implying that t...Continue Reading

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Citations

Dec 3, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Z YinY M Sin
Aug 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A J PotterT J Kavanagh
Jan 3, 2001·Free Radical Biology & Medicine·D M van ReykN H Hunt
May 23, 2001·Free Radical Biology & Medicine·M A PahlavaniA Richardson
Jan 21, 2000·Free Radical Biology & Medicine·H SauerM Wartenberg
Mar 14, 2000·Current Opinion in Immunology·P MarrackJ Kappler
Jun 5, 2010·Cell Death and Differentiation·J L SardinaA Hernández-Hernández
Feb 28, 2001·Antioxidants & Redox Signaling·L MoldovanP J Goldschmidt-Clermont
Apr 22, 2011·Critical Reviews in Oncology/hematology·José L SardinaAngel Hernández-Hernández
Jun 9, 2004·Free Radical Biology & Medicine·David A Hildeman
Nov 29, 2012·Cell Cycle·Dafne ItalianoEleonora Candi
Jun 30, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·José I Sánchez-GallegoMarcial Llanillo
May 16, 2017·Antioxidants·Rodrigo Prieto-Bermejo, Angel Hernández-Hernández
Mar 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcin M KaminskiKarsten Gülow

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