Oxidative status in children and adolescents with autoimmune thyroiditis

Clinical and Experimental Medicine
Kotb Abbass MetwalleyHisham A K Othman

Abstract

Oxidative status in autoimmune thyroiditis (AIT) has not been investigated previously in children and adolescents. We investigated oxidant and antioxidant systems in a cohort of Egyptian children and adolescents with AIT to explore these as biomarkers of autoimmunity and thyroid function. Our case control study included 32 children with AIT and 32 healthy subjects with matching age and sex as a control group. After a thorough history and physical examination, a thyroid ultrasound, measurements of thyroid-stimulating hormone (TSH), free thyroxin (FT4), antithyroid peroxidase antibodies (TPOAb), and antithyroglobulin antibody were done with assessment of malondialdehyde (MDA) and total antioxidant capacity (TAC) levels as oxidative stress markers. Overt hypothyroidism was detected in 23/32, while subclinical hypothyroidism was detected in nine of the 32 studied patients. MDA levels were significantly elevated, while TAC levels were significantly decreased in AIT patients compared with healthy controls. The difference was more evident in patients with overt hypothyroidism than those with subclinical hypothyroidism. We also observed significant positive correlations of TPOAb levels with age, TSH, MDA, and thyroid volume, finding a ...Continue Reading

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Citations

Jan 7, 2016·British Journal of Haematology·Takashi WatanabeShinsuke Iida
Jun 28, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Onur ErolNecat Yılmaz
Jan 4, 2017·The International Journal of Neuroscience·Yuanyuan HuangXu Zhang
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Jul 13, 2021·Frontiers in Endocrinology·Qin XiaTing Chen

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