Oxidative stress and abdominal aortic aneurysm: potential treatment targets

Clinical Science
Theophilus I EmetoJonathan Golledge

Abstract

Abdominal aortic aneurysm (AAA) is a significant cause of mortality in older adults. A key mechanism implicated in AAA pathogenesis is inflammation and the associated production of reactive oxygen species (ROS) and oxidative stress. These have been suggested to promote degradation of the extracellular matrix (ECM) and vascular smooth muscle apoptosis. Experimental and human association studies suggest that ROS can be favourably modified to limit AAA formation and progression. In the present review, we discuss mechanisms potentially linking ROS to AAA pathogenesis and highlight potential treatment strategies targeting ROS. Currently, none of these strategies has been shown to be effective in clinical practice.

References

Feb 1, 1987·Proceedings of the Society for Experimental Biology and Medicine·M A DubickC L Keen
Apr 24, 1993·Lancet·E N FrankelJ E Kinsella
Jun 1, 1996·The Journal of Surgical Research·D R HolmesJ M Reilly
Nov 18, 1996·Annals of the New York Academy of Sciences·R W Thompson, W C Parks
Mar 1, 1997·Experimental Physiology·H Sies
May 1, 1997·Journal of Vascular Surgery·D R HolmesJ M Reilly
Oct 9, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·V DavisB T Baxter
Aug 14, 1999·The Journal of Biological Chemistry·A R Brash
Aug 5, 2000·Free Radical Biology & Medicine·J M May
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M YoshidaJ A Whitsett
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E BråkenhielmY Cao
Jan 15, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·M C VerhaarT J Rabelink
Apr 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Francis J MillerNeal L Weintraub
Aug 16, 2002·Diabetes, Obesity & Metabolism·Karsten Schrör
Aug 17, 2002·Thrombosis Research·Martin SchillingerErich Minar
Dec 17, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Francis J Miller
Dec 17, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Takeshi K NakahashiRonald L Dalman
Feb 1, 2003·The Journal of Biological Chemistry·Jian-Mei Li, Ajay M Shah
Sep 6, 2003·American Journal of Physiology. Heart and Circulatory Physiology·J Scott McNallyDavid G Harrison
Nov 1, 2003·Antioxidants & Redox Signaling·Regina M DayBarry L Fanburg
Dec 4, 2003·Circulation Research·Hideyuki YamawakiBradford C Berk
Jan 24, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Alan Daugherty, Lisa A Cassis
Jan 24, 2004·Applied Microbiology and Biotechnology·J V Smith, Y Luo
Apr 27, 2004·Journal of Applied Physiology·Li ZuoThomas L Clanton
Sep 4, 2004·American Journal of Physiology. Heart and Circulatory Physiology·David S WeberKathy K Griendling
Sep 24, 2004·Physiological Reviews·Roland Stocker, John F Keaney
Jun 4, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Dan GavrilaNeal L Weintraub

❮ Previous
Next ❯

Citations

Aug 17, 2016·International Journal of Molecular Sciences·Jiaze LiJonathan Golledge
Sep 20, 2016·Journal of Vascular Surgery·Jonathan GolledgeRonald L Dalman
Apr 22, 2017·British Journal of Pharmacology·Qishan ChenLi Zhang
Nov 4, 2017·International Journal of Molecular Sciences·Jose Luis Martin-VenturaAna M Briones
Sep 28, 2017·Journal of Cardiovascular Pharmacology·Shi-Lan ZhangLing Liu
Dec 14, 2017·Frontiers in Physiology·Tetsuo HorimatsuNeal L Weintraub
Jun 7, 2018·Physiological Reviews·Steven J ForresterSatoru Eguchi
May 26, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Hong Lu, Alan Daugherty
Oct 12, 2018·British Journal of Pharmacology·Yunxia WangRong Qi
Dec 21, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Luca PiacentiniGualtiero Ivanoe Colombo
Feb 28, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Frank M DavisHong S Lu
Aug 14, 2019·International Journal of Molecular Sciences·Łukasz GutowskiDorota Formanowicz
Apr 24, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·Sheng LeJiahong Xia
May 29, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shih-Hung TsaiYu-Juei Hsu
Aug 10, 2019·Current Pathobiology Reports·Ana CartayaEdward M Bahnson
Dec 25, 2016·Clinical Science·Michael J Ryan
May 8, 2018·Frontiers in Cardiovascular Medicine·Sai Wang SetoAlan Bensoussan
Apr 8, 2017·Frontiers in Cardiovascular Medicine·Theophilus I EmetoJonathan Golledge
Oct 15, 2019·PeerJ·Siliang ChenYuehong Zheng
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Iwona Jarocka-KarpowiczZenon Dionizy Mariak
Dec 20, 2018·International Journal of Molecular Sciences·Dahn L ClemensDaniel R Anderson
Mar 9, 2021·Journal of Atherosclerosis and Thrombosis·Jinyun ShiMasaaki Miyata
Apr 13, 2021·Expert Review of Proteomics·Jianqiang WuYuehong Zheng
May 1, 2021·Antioxidants·David Sánchez-InfantesMaría Galán
Jul 6, 2021·Cardiovascular Therapeutics·Mingqi OuyangBilian Yu
Jul 27, 2021·Oxidative Medicine and Cellular Longevity·Yanshuo HanJian Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Journal of Vascular Surgery
Evan J RyerHelena Kuivaniemi
Arteriosclerosis, Thrombosis, and Vascular Biology
Michael L McCormickNeal L Weintraub
© 2021 Meta ULC. All rights reserved