Oxidative Stress and Aberrant Cell Cycle in Alzheimer's Disease Lymphocytes: Diagnostic Prospects

Journal of Alzheimer's Disease : JAD
Joanna WojsiatUrszula Wojda

Abstract

In Alzheimer's disease (AD), molecular changes are observed not only in patients' neurons but also in peripheral cells, such as blood lymphocytes. These include changes in the level of oxidative stress markers, mitochondria impairment, and aberrant cell cycle regulation in AD blood lymphocytes. While the concepts of early causes of AD are currently highly controversial, these findings provide support for the cell cycle hypothesis of AD pathomechanism and emphasize the systemic nature of the disease. Moreover, because of difficulties in studying dynamic processes in the human brain, lymphocytes seem to be useful for readout of AD molecular mechanisms. In addition, lymphocytes as easily accessible human cells have potential diagnostic value. We summarize current perspectives for the development of new therapeutic strategies based on oxidative stress and cell cycle dysregulation in AD, and for diagnostic methodologies involving new markers in AD lymphocytes.

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Citations

Dec 8, 2015·Biomarkers in Medicine·Urszula Wojda
Sep 9, 2015·Frontiers in Medicine·Adonis SferaCarolina Osorio
Oct 5, 2017·Biomarkers in Medicine·Joanna WojsiatUrszula Wojda
Sep 12, 2019·Frontiers in Pharmacology·Giovanna Cenini, Wolfgang Voos
Apr 11, 2018·Oxidative Medicine and Cellular Longevity·Joanna WojsiatUrszula Wojda
Oct 16, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Fang HuangXiaochuan Wang
Sep 22, 2017·American Journal of Alzheimer's Disease and Other Dementias·Andrea VergalloUbaldo Bonuccelli
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Feb 15, 2018·Journal of Alzheimer's Disease : JAD·Michalina WezykCezary Zekanowski
Feb 4, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mingchao ShiJie Zhu
Jan 16, 2021·International Journal of Molecular Sciences·Margarita A SazonovaIgor A Sobenin
Mar 3, 2021·European Journal of Medicinal Chemistry·Sukriti SrivastavaSunil Kumar Khare
May 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Serap Nigdelioglu DolanbayBelma Aslim
Jun 29, 2021·Experimental Gerontology·Alessandra GalloRomain Verpillot
Sep 4, 2020·Journal of Neurochemistry·Marah C RuntschStefano Angiari
Jul 18, 2021·Ageing Research Reviews·Kai-Min WuJin-Tai Yu
Oct 26, 2021·Frontiers in Medicine·Zarema AlbakovaAlexander Sapozhnikov

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