Oxidative stress and changes in antioxidative defense system in erythrocytes of preeclampsia in women

Reproductive Toxicology
Natasa Z DordevićZorica S Saicić

Abstract

The present study was designed to investigate whether oxidative stress occurred to erythrocytes in preeclampsia and was related to disease. Indicative markers of oxidative stress and changes in antioxidant defense system were assayed in the erythrocytes of 22 healthy pregnant and 20 women with preeclampsia. Results of our work indicated high concentration of hydrogen peroxide, nitrite, peroxynitrite and lipid peroxides in preeclampsia compared to healthy pregnant women. Concentration of superoxide anion was lower in preeclamptic women. There were no differences in concentrations of vitamin E, reduced glutathione and oxidized glutathione. Activity of glutathione-S-transferase (GST) was higher while activities of superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR) were lower in preeclamptic women. There were no differences in glutathione peroxidase (GSH-Px) activity between the two investigated groups. These results suggest that preeclampsia was characterized by oxidative stress and alteration of antioxidative defense system by disbalance in oxidative/antioxidative status of erythrocytes.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Aug 22, 1977·Biochemical and Biophysical Research Communications·J MaralA M Michelson
Aug 1, 1992·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·R Dargel
Jan 1, 1984·Methods in Enzymology·I D Desai
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Dec 1, 1996·American Journal of Hypertension·B C Jubelin, J L Gierman
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·A DenicolaR Radi
Apr 1, 1999·Nitric Oxide : Biology and Chemistry·C Herce-PagliaiD E Shuker
Aug 17, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·V M NeefjesC E Blanco
Nov 24, 1999·Reproductive Toxicology·R E Little, B C Gladen
Nov 24, 1999·Free Radical Biology & Medicine·O W Griffith
Dec 22, 1999·Proceedings of the Society for Experimental Biology and Medicine·C A Hubel
Apr 25, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·E Y SözmenT Onat
Nov 18, 2000·American Journal of Physiology. Cell Physiology·J M MayC E Cobb
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Jun 14, 2002·Placenta·J M Roberts, K Y Lain
Feb 26, 2004·American Journal of Obstetrics and Gynecology·Bartira Pinheiro da CostaCarlos E Poli de Figueiredo
Jul 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Xunde WangMark T Gladwin
Jan 1, 1972·Methods in Enzymology·J F Riordan, B L Vallee

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Citations

Jun 6, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Maja LazarusMaja Blanuša
Jul 24, 2010·Biological Trace Element Research·Maja LazarusMaja Blanuša
Jan 8, 2009·Antioxidants & Redox Signaling·Joern R SteinertGiovanni E Mann
Feb 24, 2011·Archives of Gynecology and Obstetrics·Habibe GencOnur Güralp
Nov 5, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Suchitra RoySadhana Joshi
Mar 5, 2015·International Journal of Molecular Sciences·Keiichi MatsubaraAkihiro Nawa
Nov 17, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Aleksandra NikolicZoran Stosic
Apr 25, 2009·Free Radical Biology & Medicine·Tracey A MillsSusan L Greenwood
Oct 20, 2015·Gynécologie, obstétrique & fertilité·P GuerbyA Negre-Salvayre
Feb 22, 2012·British Journal of Pharmacology·S K WalshL C Kenny
Jul 6, 2010·The International Journal of Biochemistry & Cell Biology·Kaïs H Al-GuboryCatherine Garrel
Feb 1, 2017·Journal of Cardiovascular Pharmacology·Jude S MortonSandra T Davidge
Aug 7, 2009·Reproductive Sciences·Elizabeth TurnerJulie Fisher
Nov 17, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tanja R NovakovicNatasa Z Djordjevic
Jun 16, 2010·Archives of Gynecology and Obstetrics·Imran A SiddiquiHanan M F Al Kadri
Aug 24, 2018·Biology of Reproduction·Hamid-Reza Kohan-GhadrSascha Drewlo
Nov 29, 2014·Journal of Biosciences·Marko D ProkicZorica S Saicic
Apr 25, 2018·Obstetrics and Gynecology International·Márcia Aires Rodrigues de FreitasNilson Penha-Silva
Jan 28, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ali KolusariMansur Kamaci
Jan 8, 2021·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Aditi A GodhamgaonkarSadhana R Joshi
Jun 25, 2021·Drug Design, Development and Therapy·Chang ShuCong Hu
Nov 12, 2009·Reproductive Toxicology·Natasa Z DjordjevićZorica S Saicić

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