PMID: 15368706Sep 17, 2004Paper

Oxidative stress and coenzyme Q10 supplementation in renal transplant recipients

International Urology and Nephrology
A DługoszM Boratyńska

Abstract

Recently some reports about the oxidative stress in renal transplant recipients have been published. The role of coenzyme Q10 (CoQ10) as radical scavanger is largely known. The aim of our study was to evaluate the protective role of CoQ10 in renal transplant recipients on lipid peroxidation and lipids parameters, as well as its influence on antioxidant enzymes, neutrophils chemiluminescence and urinary enzymes. The study was performed in 11 long term allograft recipients treated additionally with CoQ10 90 mg/day in three doses, 30 mg each for four weeks. The malonyldialdehyde (MDA) and 4-hydroxynonenal (4-HNE), superoxide dismutase (SOD) and glutathione peroxidase (GPx) and the basic parameters of lipid metabolism such as total cholesterol (TC), high and low density lipoproteins (HDL, LDL), triglycerides (TG), atherogenicity indicators [LDL/HDL; (TC-HDL)/HDL] were evaluated. The chemiluminescence of neutrophils (luminol, fLMP-method) were mesured and the activity of N-acetyl-beta-D-glucosaminidase (NAG), alanylaminopeptidase (AAP), elastase, alpha-1-antitrypsin. All parameters were estimated before and after CoQ10 treatment. Statistically significant changes were noticed with the LDL and atherogenicity indicators (p < 0.01) (de...Continue Reading

Citations

Feb 21, 2008·The British Journal of Nutrition·Michihiro KonIchiro Kono
Jan 25, 2013·Advances in Pharmacological Sciences·Azza A K El-SheikhAly M Abdelrahman
May 6, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Kazuhiro ShimizuIchiro Kono
Mar 24, 2017·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Andriy V TrailinOlexander S Nikonenko
May 5, 2012·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Akira Ishikawa, Yukio Homma
Oct 18, 2019·Cell Stress & Chaperones·Daniela Sayuri MizobutiElaine Minatel
Apr 30, 2020·Mini Reviews in Medicinal Chemistry·Pragati SilakariPoonam Piplani

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