Oxidative stress and endothelial function in normal pregnancy versus pre-eclampsia, a combined longitudinal and case control study

BMC Pregnancy and Childbirth
Dominique MannaertsYves Jacquemyn

Abstract

Pre-eclampsia (PE) is related to an impaired endothelial function. Endothelial dysfunction accounts for altered vascular reactivity, activation of the coagulation cascade and loss of vascular integrity. Impaired endothelial function originates from production of inflammatory and cytotoxic factors by the ischemic placenta and results in systemic oxidative stress (OS) and an altered bioavailability of nitric oxide (•NO). The free radical •NO, is an endogenous endothelium-derived relaxing factor influencing endothelial function. In placental circulation, endothelial release of •NO dilates the fetal placental vascular bed, ensuring feto-maternal exchange. The Endopreg study was designed to evaluate in vivo endothelial function and to quantify in vitro OS in normal and pre-eclamptic pregnancies. The study is divided into two arms, a prospective longitudinal study and a matched case control study. In the longitudinal study, pregnant patients ≥18 years old with a singleton pregnancy will be followed throughout pregnancy and until 6 months post-partum. In the case control study, cases with PE will be compared to matched normotensive pregnant women. Maternal blood concentration of superoxide (O2•) and placental concentration of •NO will...Continue Reading

Associated Clinical Trials

References

Apr 1, 1986·American Journal of Obstetrics and Gynecology·S G TygartD Z Kitay
Jan 12, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·R SlimB Hennig
Sep 16, 2000·Hypertension·A YoshidaH Kobayashi
Jan 7, 2004·Gynecologic and Obstetric Investigation·Yves JacquemynChristel Van Campenhout
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
Feb 3, 2006·The European Respiratory Journal·D YinonG Pillar
Jun 8, 2007·Microvascular Research·Walter P Mutter, S Ananth Karumanchi
Aug 22, 2007·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Ann E QuintonMichael J Peek
Sep 28, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·W PlasenciaK H Nicolaides
Nov 3, 2007·BMJ : British Medical Journal·Leanne BellamyDavid J Williams
May 17, 2008·Journal of the American College of Cardiology·Tommaso GoriJohn D Parker
Dec 9, 2008·American Heart Journal·Sarah D McDonaldPhilip J Devereaux
Dec 17, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·A A KhalilK F Harrington
Oct 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Dick H J ThijssenDaniel J Green
Dec 7, 2010·Best Practice & Research. Clinical Obstetrics & Gynaecology·Graham J Burton, Eric Jauniaux
Jun 7, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A Cristina Rossi, Patrick M Mullin
Nov 5, 2011·Journal of Hypertension·David M CartyChristian Delles
Dec 3, 2011·Journal of Hypertension·Anaïs HausvaterStella S Daskalopoulou
Oct 31, 2012·Current Opinion in Obstetrics & Gynecology·Madhavi KalidindiJoseph Aquilina
Jan 23, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·I-Kuan WangDonald E Morisky
Jan 21, 2014·Reproductive Sciences·Chahinda Ghossein-DohaLouis Peeters
Mar 14, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·G J HofmeyrUNKNOWN Calcium and Pre-eclampsia (CAP) Study Group
Mar 19, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Emel KurtogluErdal Malatyalioglu
Apr 2, 2014·Hypertension·Leslie MyattUNKNOWN Global Pregnancy CoLaboratory
Jul 30, 2014·Nitric Oxide : Biology and Chemistry·Morten Hedetoft, Niels Vidiendal Olsen
Aug 21, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·N M BreetveldMea Spaanderman
Sep 10, 2014·Frontiers in Physiology·Lesia O KurlakFiona Broughton Pipkin
Oct 28, 2014·Frontiers in Physiology·Lissette C Sánchez-ArangurenMarcos Lopez
Jan 8, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jan F GielisPaul E Y Van Schil
Jul 15, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Selda Demircan Sezerİmran Kurt Ömürlü
Sep 13, 2015·Current Hypertension Reports·Leslie Myatt, James M Roberts
Oct 13, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mohamed Abdel RazikAmrr Sharafeldeen
Nov 22, 2015·American Journal of Reproductive Immunology : AJRI·Fan WuWang-Ming Xu
Dec 19, 2015·Global Health, Science and Practice·Stephen Hodgins
Jan 7, 2016·The New England Journal of Medicine·Harald ZeislerStefan Verlohren
Mar 10, 2016·Pregnancy Hypertension·Salih SerinHakan Kıran
Jan 4, 2017·American Journal of Obstetrics and Gynecology·Kelly K FergusonDavid E Cantonwine
Feb 28, 2017·American Journal of Reproductive Immunology : AJRI·Zakia SultanaRoger Smith
Aug 11, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dominique MannaertsYves Jacquemyn

❮ Previous
Next ❯

Citations

Feb 21, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Araceli Jarquin CamposMartin Risch
Aug 20, 2019·Neurology·Cande V AnanthAnne-Marie Nybo Andersen
Mar 7, 2020·Journal of Cellular and Molecular Medicine·Miguel A OrtegaNatalio García-Honduvilla
Aug 25, 2018·Oxidative Medicine and Cellular Longevity·Serafina PerroneGiuseppe Buonocore
Jul 13, 2020·Molecular Biology Reports·Esther Alves de Souza, Luciana Pellegrini Pisani
Mar 29, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Anna WnukDariusz Szukiewicz
Dec 28, 2018·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Delia I ChiarelloReinaldo Marín
Sep 25, 2021·Environmental Science and Pollution Research International·Sulagna DuttaPallav Sengupta

❮ Previous
Next ❯

Software Mentioned

Bruker WINEPR -
Sphygmocor

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.