Oxidative stress and functional deficit in diabetic cardiomyopathy

Advances in Experimental Medicine and Biology
P K SingalV Sandhawalia

Abstract

When the equilibrium between free-radical production and cellular antioxidant defences is disturbed in favour of more free radicals, it causes oxidative stress which can promote cellular injury. Oxidative stress has been suggested to play a role in the pathogenesis of diabetic cardiomyopathy. In streptozotocin-induced diabetes, there is a decrease in antioxidant enzyme activities and an increase in myocardial lipid peroxidation. Probucol, an antioxidant, was found to improve cardiac function which may have been due to an increase in myocardial antioxidant enzyme activities and a decrease in lipid peroxidation in the diabetic animals. Some of the beneficial effects of probucol may also be due to an improvement in plasma insulin levels and a decrease in the plasma glucose. The diabetic state is also associated with endothelial dysfunction, retinopathy, neuropathy and renopathy. Some of these secondary complications may also be mediated by oxidative stress. It is suggested that diabetic cardiomyopathy is associated with an antioxidant deficit and that antioxidant therapy may be useful in improving cardiac function in diabetes.

Citations

Nov 30, 2006·The Journal of Pharmacy and Pharmacology·M Amarnath Satheesh, L Pari
Mar 3, 2012·Applied Microbiology and Biotechnology·Yeu-Ching Shi, Tzu-Ming Pan
Jun 30, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Bing HanJohn Anthony Bauer
May 21, 2015·Journal of Zhejiang University. Science. B·Hai-tao YuSui-sheng Wu
Sep 7, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Lin YanDorothy E Vatner
Dec 19, 2002·Molecular Pharmacology·Tadeusz PawelczykMonika Sakowicz
Dec 6, 2012·Canadian Journal of Physiology and Pharmacology·Justin L RainsSushil K Jain
May 7, 2015·Oxidative Medicine and Cellular Longevity·Stephen F VatnerDorothy E Vatner
Jul 17, 2015·Journal of Applied Toxicology : JAT·Guang WangXuesong Yang
Oct 30, 2004·Medicine and Science in Sports and Exercise·Yvonne M SearlsLisa Stehno-Bittel
May 25, 2007·Current Heart Failure Reports·Hadi N Skouri, W H Wilson Tang
Feb 1, 2019·Journal of Cellular and Molecular Medicine·Leilei YinXinhua Yin
Jul 6, 2005·The Tohoku Journal of Experimental Medicine·Oguz OzcelikHaluk Kelestimur
Jul 7, 2017·Canadian Journal of Physiology and Pharmacology·Martina MurárikováTáňa Ravingerová
Jul 12, 2005·Diabetes Research and Clinical Practice·Renata FranzonAngela T S Wyse
Sep 9, 2006·Endocrinology and Metabolism Clinics of North America·Gregg C Fonarow, Preethi Srikanthan
Dec 8, 2007·Cardiology Clinics·David S H Bell
Jul 2, 2008·The American Journal of Cardiology·Maria Antonietta PellegrinoGiuseppe D'Antona
Dec 7, 2010·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Mohana ThiruchenduranSivasitambaram Niranjali Devaraj

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