Oxidative Stress and IgG Antibody Modify Periodontitis-CRP Association

Journal of Dental Research
R E SingerSteven Offenbacher

Abstract

In a previous report, we demonstrated the inverse association of high serum 8-isoprostane levels, a marker for oxidative stress, with decreased serum IgG antibodies to oral bacteria. The association between increased serum IgG with increased plaque and periodontitis (increased probing depths) was attenuated by high systemic oxidative stress. Other investigations have reported a role for systemic oxidative stress as a stimulus of hepatic C-reactive protein (CRP) response. These observations led us to hypothesize that the reported relationship of periodontitis to elevated serum CRP, a systemic inflammatory marker, may be modified by oxidative stress and that the levels of serum antibodies to oral bacteria might be an intermediary explanatory variable linking the association of systemic oxidative stress, periodontal disease, and levels of CRP. This hypothesis was explored as a secondary analysis of the Dental ARIC (Atherosclerosis Risk in Communities) study using serum levels of CRP, serum IgG levels to 16 oral organisms, serum levels of 8-isoprostane, and periodontal status. The findings indicate periodontitis is associated with high CRP in the presence of elevated oxidative stress that serves to suppress the IgG response. Only w...Continue Reading

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Citations

Jan 26, 2016·Antioxidants·Maria GreabuBogdan Calenic
Apr 19, 2017·Journal of Clinical Periodontology·Luiz Felipe C FrançaDaniel F P Vasconcelos
Jan 10, 2018·Frontiers in Physiology·L'ubomíra Tóthová, Peter Celec
May 10, 2020·Periodontology 2000·Harvey A SchenkeinMariano Sanz
Feb 8, 2019·Critical Reviews in Microbiology·Aditi Chopra, Karthik Sivaraman

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