Oxidative stress and its association with TNF-α-308 G/C and IL-1α-889 C/T gene polymorphisms in patients with diabetes and diabetic nephropathy

Gene
Brijesh Dabhi, Kinnari N Mistry

Abstract

Diabetic nephropathy is one of the major complications of type 2 diabetes and it is currently the leading cause of end-stage renal disease. The stimulus for the increase in inflammation in diabetes is still under investigation; however, reactive oxygen species might be a primary source. This study was conducted in four groups in West Indian population: control (235), type 2 diabetes (DM) (214), nephropathy with diabetes (DN) (188) and nephropathy without diabetes (NDN) (196). Oxidative stress markers such as malondialdehyde (MDA), glutathione (GSH), superoxide dismutase and catalase were measured in all the groups. TNF-α-308 G/C and IL-1α-889 C/T polymorphisms were analyzed using PCR-RFLP method. Correlations between genotype frequency and the level of oxidative stress markers were examined. MDA was significantly increased in the patient group in comparison to control group. GSH and SOD were significantly decreased in the patient group in comparison to control group. There was no significant difference observed in genotype frequency of TNF-α in the patient group compared with control group. IL-1α-889 C/T polymorphism may be associated with diabetic nephropathy. Moreover there was no association of TNF-α-308 G/C polymorphism wit...Continue Reading

References

Jul 20, 1999·Kidney International·D SankaranI V Hutchinson
Nov 16, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E RitzS Halimi
May 7, 2002·Genomics·Martin J H NicklinKen Kornman
Jul 17, 2004·Histochemistry and Cell Biology·George L King, Mary R Loeken
Aug 7, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A TsiavouS A Raptis
Jun 16, 2005·Kidney International·James B WetmoreKirsten L Johansen
Feb 10, 2006·Current Medical Research and Opinion·Eva M Vivian
Jan 24, 2007·Physiological Reviews·Karen Bedard, Karl-Heinz Krause
Aug 16, 2008·Reviews in Endocrine & Metabolic Disorders·Sebastian MartiniMatthias Kretzler
Nov 29, 2008·Molecular and Cellular Endocrinology·David Nathanson, Thomas Nyström
Oct 31, 2009·Diabetes Research and Clinical Practice·Mohammad Kazemi ArababadiReza Derakhshan
Jan 3, 2012·Indian Journal of Clinical Biochemistry : IJCB·Sarita N ShindeAdinath N Suryakar

❮ Previous
Next ❯

Citations

Nov 9, 2016·Journal of Diabetes Research·Geisa Izetti LunaMauro Niskier Sanchez
Jul 18, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Shadia A FathyAbdulnabi T Alattar
Oct 27, 2015·Frontiers in Biology·Shuxia Wang
Apr 19, 2020·Molecular and Cellular Biochemistry·Varadaraj VasudevanGovindan Sadasivam Selvam
May 6, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Mengwei LiuWanyang Liu
Jan 16, 2021·Food & Nutrition Research·Kung-Chi ChanYun-Chin Chung
Dec 8, 2020·International Archives of Allergy and Immunology·Suqin WangLingling Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.