Oxidative Stress and Its Clinical Applications in Dementia

Journal of Neurodegenerative Diseases
Peizhong Mao

Abstract

Dementia is a complex disorder that mostly affects the elderly and represents a significant and growing public health burden in the world. Alzheimer's disease (AD)- associated dementia and dementia with Lewy bodies (DLB) are the most common forms of dementia, in which oxidative stress is significantly involved. Oxidative stress mechanisms may have clinical applications, that is, providing information for potential biomarkers. Thus brain-rich peptides with an antioxidant property, such as CART (cocaine- and amphetamine-regulated transcript), may be promising new markers. This paper summarizes the progress in research regarding oxidative stress in dementia with a focus on potential biomarkers in the cerebrospinal fluid (CSF) in the main forms of dementia. Other central and peripheral biomarkers, especially those considered oxidative stress related, are also discussed. This paper aims to provide information to improve current understanding of the pathogenesis and progression of dementia. It also offers insight into the differential diagnosis of AD and DLB.

References

Nov 1, 1995·Trends in Neurosciences·R A Nixon, A M Cataldo
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·M A SmithG Perry
Mar 3, 1998·Neurochemical Research·M R PrasadW R Markesbery
Dec 5, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D PraticòG A Fitzgerald
Feb 4, 1999·Journal of Neurochemistry·J Nourooz-ZadehB Halliwell
Feb 20, 1999·Neurology·T J MontineJ D Morrow
Mar 30, 1999·Journal of Molecular Neuroscience : MN·M Y AksenovW R Markesbery
Sep 6, 2000·Proceedings. Biological Sciences·J Smythies
Aug 7, 2001·Journal of Neuropathology and Experimental Neurology·A NunomuraM A Smith
Sep 5, 2002·Free Radical Biology & Medicine·Thomas J MontineJason D Morrow
Feb 5, 2003·Seminars in Clinical Neuropsychiatry·Ian G McKeithJohn T O'Brien
Mar 24, 2004·Chemistry and Physics of Lipids·Kathleen S MontineThomas J Montine
Aug 25, 2004·Journal of Internal Medicine·M J de LeonH Rusinek
Mar 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giselle P LimGreg M Cole
May 10, 2005·Science·Samuel E SchrinerPeter S Rabinovitch
Aug 23, 2005·Lancet·A M ValdesT D Spector
Sep 6, 2005·Journal of Neuropathology and Experimental Neurology·Esther DalfóIsidre Ferrer
Oct 21, 2005·Neurology·I G McKeithUNKNOWN Consortium on DLB
Oct 14, 2006·Journal of Neural Transmission·R Schliebs, T Arendt
Dec 15, 2006·Neurobiology of Aging·Esther Dalfó, Isidre Ferrer
Feb 3, 2007·Brain : a Journal of Neurology·Jennifer L WhitwellClifford R Jack
Mar 29, 2007·Brain Pathology·James B LeverenzJing Zhang
Apr 6, 2007·Neuroscience Letters·Shino MagakiWolff M Kirsch
May 19, 2007·Journal of Neuroscience Research·Mark A Lovell, William R Markesbery
Jul 20, 2007·The European Journal of Neuroscience·Peizhong MaoNabil J Alkayed
Oct 5, 2007·Neurology·N Ertekin-TanerN R Graff-Radford
Oct 9, 2007·Neurobiology of Aging·Lidia Glodzik-SobanskaMony J de Leon
Oct 9, 2007·Neurobiology of Disease·Mark A Lovell, William R Markesbery
Nov 7, 2007·Acta Neuropathologica·Thomas Gerald BeachDouglas G Walker

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Citations

Jun 20, 2019·Journal of Clinical Medicine·Anna KlimiukAnna Zalewska
Aug 5, 2017·Molecular BioSystems·Cynthia Martins Villar CoutoLuciano da Fontoura Costa
Mar 18, 2020·Journal of Clinical Medicine·Anna KlimiukMateusz Maciejczyk
Aug 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Silvia HiltJohn C Voss
Apr 26, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rosaliana LibroEmanuela Mazzon
Jan 13, 2018·Frontiers in Neuroscience·Wenting GuoLudo Van Den Bosch

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Methods Mentioned

BETA
MDA
protein assay

Software Mentioned

CART

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