PMID: 9546938Jan 1, 1996Paper

Oxidative stress and lipids in diabetes: a role in endothelium vasodilator dysfunction?

Vascular Medicine
R M Tribe, L Poston

Abstract

Endothelial dysfunction is a key feature of diabetes mellitus and is thought to be the major cause of vascular complications associated with the disease. The vascular endothelium demonstrates impaired synthesis of vasodilators and increased release of procoagulants and vasoconstrictors, defects which theoretically could explain the increased incidence of atherosclerosis and hypertension found within this patient group. The pathways mediating endothelial cell layer dysfunction are unknown, although many candidates have been proposed. This review concentrates on the hypothesis that increased oxidative stress combined with abnormal plasma lipid composition leads to reduced synthesis of endothelial vasodilators and hence endothelial dysfunction. Free radical generation is undoubtedly raised in diabetes but the evidence for decreased antioxidant status is debatable. The role of antioxidant and lipid-lowering therapy is considered, but few studies have directly investigated the effect of treatment on vascular function. Concern arises from individual studies of vitamin E in diabetic animals which have proved deleterious. Current literature implies that a combination therapy of vitamin E and vitamin C may be beneficial, but this needs ...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H VlassaraR Bucala
Dec 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·M Boolell, J E Tooke
Sep 19, 1991·The New England Journal of Medicine·Z MakitaH Vlassara
Aug 1, 1991·Diabetes·C D StehouwerG J Den Ottolander
May 11, 1991·BMJ : British Medical Journal·D D SandemanJ E Tooke
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M KiharaP A Low
Jan 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·A CollierM Small
May 1, 1990·Diabetologia·K TakahashiS R Bloom
Aug 1, 1989·Metabolism: Clinical and Experimental·K MurakamiY Kawakami
May 17, 1986·British Medical Journal·G RaymanJ E Tooke
Nov 1, 1988·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T DohiA Tsujimoto
Jan 1, 1988·Free Radical Biology & Medicine·G M Rubanyi
May 1, 1988·Clinical Science·S A WilliamsJ E Tooke
Feb 1, 1986·Clinical Science·J E Tooke
Nov 1, 1986·Clinical Science·G F Gibbons
Jun 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A BonoL Pandolfo
Dec 2, 1986·European Journal of Pharmacology·Y OyamaM Kanno
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Nov 1, 1993·British Journal of Pharmacology·M J GriffithsT W Evans
Jan 6, 1995·The Journal of Biological Chemistry·J K LiaoS L Clark

❮ Previous
Next ❯

Citations

Aug 15, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Nandan KoppikerDavid Price
Apr 19, 2005·American Journal of Physiology. Heart and Circulatory Physiology·D K JagadeeshaRamesh C Bhalla
Jun 6, 2003·Endocrine Reviews·R N Clayton
Sep 25, 1999·Diabetes/metabolism Research and Reviews·D W LaightE E Anggård
Oct 25, 2006·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Peter N Båvenholm, Suad Efendic
Oct 11, 2007·Diabetes, Obesity & Metabolism·Sayeeda RahmanAbdul Rahman A Rashid
Apr 4, 2008·American Journal of Physiology. Cell Physiology·Neetu SudStephen M Black
Mar 10, 2004·The Journal of Pharmacy and Pharmacology·G Ozansoy, F B Akin
Feb 13, 2001·Endocrine Reviews·J Calles-Escandon, M Cipolla
Dec 4, 2001·Atherosclerosis·M C Audelin, J Genest
Oct 20, 2001·Diabetes Research and Clinical Practice·I N MigdalisC Cordopatis
Dec 2, 1999·Mechanisms of Ageing and Development·R P DanamR W Hart
Jun 4, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jorge L Ble-CastilloJuan C Díaz-Zagoya
Sep 22, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Mohammed AjebliMohamed Eddouks

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Circulation Journal : Official Journal of the Japanese Circulation Society
Yukihito HigashiYasuki Kihara
Current Diabetes Reports
Subramaniam Pennathur, Jay W Heinecke
Current Opinion in Nephrology and Hypertension
C Kitiyakara, C S Wilcox
© 2022 Meta ULC. All rights reserved