Oxidative stress and male reproductive biology

Reproduction, Fertility, and Development
R J Aitken, Mark A Baker

Abstract

Spermatozoa were the first cell type in which the cellular generation of reactive oxygen was demonstrated. This activity has now been confirmed in spermatozoa from all mammalian species examined including the rat, mouse, rabbit, horse, bull and human being. Under physiological circumstances, cellular redox activity is thought to drive the cAMP-mediated, tyrosine phosphorylation events associated with sperm capacitation. In addition to this biological role, human spermatozoa also appear to suffer from oxidative stress, with impacts on the normality of their function and the integrity of their nuclear and mitochondrial DNA. Recent studies have helped to clarify the molecular basis for the intense redox activity observed in defective human spermatozoa, the nature of the subcellular structures responsible for this activity and possible mechanisms by which oxidative stress impacts on these cells. Given the importance of oxidative damage in the male germ line to the origins of male infertility, early pregnancy loss and childhood disease, this area of sperm biochemistry deserves attention from all those interested in improved methods for the diagnosis, management and prevention of male-mediated reproductive failure.

Citations

Jul 16, 2005·Reproductive Biology and Endocrinology : RB&E·Ashok AgarwalRakesh K Sharma
Nov 11, 2005·Environmental Health : a Global Access Science Source·Gunnar ToftUNKNOWN INUENDO
Nov 30, 2005·Reproductive Biology and Endocrinology : RB&E·Mark A Baker, R John Aitken
Dec 13, 2006·Journal of the American Society for Mass Spectrometry·Hay-Yan J WangAmina S Woods
Mar 28, 2009·Proceedings. Biological Sciences·Damian K Dowling, Leigh W Simmons
Apr 29, 2010·The Journal of Clinical Investigation·Jessica EscoffierChristophe Arnoult
Nov 9, 2010·Asian Journal of Andrology·Mona BungumAleksander Giwercman
Sep 1, 2006·Indian Journal of Clinical Biochemistry : IJCB·M Maneesh, H Jayalekshmi
Dec 5, 2012·Journal of Signal Transduction·Takashi W IjiriKen-Ichi Sato

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