Oxidative stress and metabolic responses to copper in freshwater- and seawater-acclimated killifish, Fundulus heteroclitus

Aquatic Toxicology
Victoria E RansberryGrant B McClelland

Abstract

In freshwater (FW), many of the main mechanisms of copper (Cu) toxicity have been characterized; however, toxicity mechanisms in seawater (SW) are less well understood. We investigated the effects of salinity on Cu-induced oxidative stress and metabolic responses in adult killifish, Fundulus heteroclitus. We exposed FW and SW-acclimated killifish to either low Cu (LC, 50 μg/L) or high Cu (HC, 200 μg/L) for 96 h and compared them to controls (CTRL) under the same salinities without added Cu. Cu exerted minimal influence on tissue ion levels in either FW or SW. Salinity generally protected against Cu bioaccumulation in the gills and liver, but not in the carcass. Hematocrit (Hct) and hemoglobin (Hb) levels were increased by LC and HC in both FW and SW, and blood lactate was reduced in FW-killifish exposed to LC and HC. Rates of oxygen consumption were similar across treatments. Salinity reduced Cu load in gill, liver and intestine at LC but only in the gills at HC. In general, Cu increased gill, liver, and intestine catalase (CAT) activity, while superoxide dismutase (SOD) either decreased or remained unchanged depending on tissue-type. These changes did not directly correlate with levels of protein carbonyls, used as an index of...Continue Reading

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Citations

Mar 12, 2016·Aquatic Toxicology·Chris N GloverJacqueline A Lee
Aug 25, 2015·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Victoria E RansberryGrant B McClelland
Oct 30, 2015·Aquatic Toxicology·Erika Berenice Martínez-Ruiz, Fernando Martínez-Jerónimo
Nov 27, 2015·Fish Physiology and Biochemistry·Volodymyr I Lushchak
Feb 22, 2018·Fish Physiology and Biochemistry·Viktor V HusakVolodymyr I Lushchak
Feb 16, 2019·The Journal of Experimental Biology·Melanie WilliamsCarol Bucking
Aug 16, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Carol Bucking
Jan 10, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Abhipsa BalBiswaranjan Paital
Dec 30, 2018·Ecotoxicology and Environmental Safety·Shannon Weeks SantosPatrice Gonzalez

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