Oxidative Stress and Microvessel Barrier Dysfunction

Frontiers in Physiology
Pingnian HeFeng Gao

Abstract

Clinical and experimental evidence indicate that increased vascular permeability contributes to many disease-associated vascular complications. Oxidative stress with increased production of reactive oxygen species (ROS) has been implicated in a wide variety of pathological conditions, including inflammation and many cardiovascular diseases. It is thus important to identify the role of ROS and their mechanistic significance in microvessel barrier dysfunction under pathological conditions. The role of specific ROS and their cross talk in pathological processes is complex. The mechanisms of ROS-induced increases in vascular permeability remain poorly understood. The sources of ROS in diseases have been extensively reviewed at enzyme levels. This review will instead focus on the underlying mechanisms of ROS release by leukocytes, the differentiate effects and signaling mechanisms of individual ROS on endothelial cells, pericytes and microvessel barrier function, as well as the interplay of reactive oxygen species, nitric oxide, and nitrogen species in ROS-mediated vascular barrier dysfunction. As a counter balance of excessive ROS, nuclear factor erythroid 2 related factor 2 (Nrf2), a redox-sensitive cell-protective transcription f...Continue Reading

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Citations

Jul 24, 2020·Journal of Thrombosis and Thrombolysis·Richard C Becker
Aug 11, 2020·QJM : Monthly Journal of the Association of Physicians·Claire L Shovlin, Marcela P Vizcaychipi
Jun 1, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Se-Jin LeeIn-Sik Shin
Jun 18, 2021·Journal of Cardiovascular Pharmacology and Therapeutics·Dun NiuZhizhong Xie
Jul 3, 2021·Cancers·Tamara Mc ErlainCristina M Branco
Nov 25, 2021·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Anupama ChalimeswamySangly P Srinivas

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