Oxidative stress and monooxygenase liver function in patients with coronary heart disease and multiple organ dysfunction syndrome

European Journal of Anaesthesiology
V A NepomniashchikhL G Kniazkova

Abstract

The purpose of the study was to evaluate oxidative stress and liver monooxygenase function in patients with coronary heart disease and multiple organ dysfunction syndrome. Twenty-seven patients with multiple organ dysfunction and 38 patients with an uneventful postoperative period were studied. Oxidative stress was quantified with malon dialdehyde, coupled trienes, hepatocuprein and catalase activity. Liver monooxygenase function was evaluated with antipyrine pharmacokinetics data. On the first postoperative day patients with multiple organ dysfunction were characterized by high lipid peroxidation (conjugated trienes: +84.7%) and significant decrease in liver monooxygenase function (clearance of antipyrine: -38%), whereas control patients had a mild oxidative stress and a slight depression in liver monooxygenase function. On the third to fourth postoperative day in both groups a considerable intensity of lipid peroxidation and increase in liver metabolism was seen. The major difference was observed on postoperative days 10-12. In both groups oxidative stress intensity decreased (conjugated trienes: +34.7%; +12.9%). In the main group liver monooxygenase function was markedly depressed (clearance of antipyrine: -35.6%), whereas i...Continue Reading

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Citations

Jun 20, 2014·Internal Medicine Journal·Y ZhouC Jia

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