Oxidative Stress and Oral Mucosal Diseases: An Overview

In Vivo
Nicola SardaroMassimo Petruzzi

Abstract

Reactive oxygen species (ROS) and free radicals are physiologically produced during cellular metabolism. When their balance is disrupted in favor of ROS, a condition called oxidative stress occurs. Oxidative stress represents a widespread phenomenon involved in several pathological conditions. The aim of the present review was to report current knowledge on oxidative stress related to oral mucosal diseases. Articles from 2000 to 2018 were selected for relevance, validity and quality, from results obtained in PubMed, MEDLINE and Google Scholar using the following search terms: oxidative stress and oral lichen, oral pemphigus, aphthous stomatitis, oral leukoplakia, oral cancer, oral squamous cell carcinoma and oral carcinoma. All articles were independently screened for eligibility by the authors. This narrative review integrates extensive information from all relevant published studies focusing on oxidative stress in oral mucosal diseases. We outline the pathogenetic function of oxidative stress in the most frequent inflammatory, potentially malignant and malignant diseases of the oral mucosa and provide detailed findings from human research. Although variability in findings between individual studies exists, it justifies the co...Continue Reading

Citations

Jul 10, 2019·International Journal of Dermatology·Maria ContaldoAlberta Lucchese
Sep 14, 2019·Journal of International Society of Preventive & Community Dentistry·Kumar Chandan Srivastava
Jan 28, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Fedora Della VellaMassimo Petruzzi
Feb 16, 2021·Frontiers in Nutrition·Mathieu SchwartzFrancis Canon
Apr 27, 2021·BioMed Research International·Wanchen NingXianda Hu
Apr 15, 2020·Experimental and Molecular Pathology·Farzaneh Agha-HosseiniMahdieh-Sadat Moosavi

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