PMID: 8964187Feb 1, 1996Paper

Oxidative stress and platelet activation in diabetes mellitus

Diabetes Research and Clinical Practice
F Catella-Lawson, G A FitzGerald

Abstract

The role of oxidative stress and platelet activation in the development and evolution of diabetic vascular complications is unclear. They can both be the consequence of established vascular disease or a contributing factor to the evolution of atherosclerosis. Free radical generation may both lead to or result from platelet activation, suggesting that oxidative stress and platelet activation may be closely interrelated. Controversial results may partly reflect methodological constraints. Novel techniques for the measurement of in vivo indices of oxidant injury have been developed and will be used in conjunction with pharmacological probes to establish whether oxidative stress is enhanced in diabetes and whether this preceeds the onset of micro and macrovascular disease.

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Citations

Aug 1, 2000·Indian Journal of Clinical Biochemistry : IJCB·K GoswamiR Shankar
Mar 24, 2004·Chemistry and Physics of Lipids·Domenico PraticòGarret A FitzGerald
Mar 24, 2004·Chemistry and Physics of Lipids·Giovanni DavìCarlo Patrono
Feb 1, 2000·Revue de l'infirmière·J B Vercken
May 17, 2002·Journal of Diabetes and Its Complications·Aaron Vinik, Mark Flemmer
Jan 15, 2005·Antioxidants & Redox Signaling·Giovanni DavìCarlo Patrono

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