Oxidative stress and redox regulation on hippocampal-dependent cognitive functions

Archives of Biochemistry and Biophysics
Ting-Ting HuangYani Zou

Abstract

Hippocampal-dependent cognitive functions rely on production of new neurons and maintenance of dendritic structures to provide the synaptic plasticity needed for learning and formation of new memories. Hippocampal formation is exquisitely sensitive to patho-physiological changes, and reduced antioxidant capacity and exposure to low dose irradiation can significantly impede hippocampal-dependent functions of learning and memory by reducing the production of new neurons and alter dendritic structures in the hippocampus. Although the mechanism leading to impaired cognitive functions is complex, persistent oxidative stress likely plays an important role in the SOD-deficient and radiation-exposed hippocampal environment. Aging is associated with increased production of pro-oxidants and accumulation of oxidative end products. Similar to the hippocampal defects observed in SOD-deficient mice and mice exposed to low dose irradiation, reduced capacity in learning and memory, diminishing hippocampal neurogenesis, and altered dendritic network are universal in the aging brains. Given the similarities in cellular and structural changes in the aged, SOD-deficient, and radiation-exposed hippocampal environment and the corresponding changes i...Continue Reading

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Citations

Sep 1, 2015·NeuroImage·Christine Lucas TardifArno Villringer
Jul 19, 2016·Neuroscience and Biobehavioral Reviews·Joukje M Oosterman, Dieuwke S Veldhuijzen
Oct 21, 2016·Redox Biology·Calina BetlazarGuo-Jun Liu
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Jul 11, 2018·International Journal of Molecular Sciences·Minyu ZhangHongjun Yang
Aug 3, 2019·Lasers in Medical Science·Reza Meynaghizadeh-ZargarSeyed Hossein Rasta
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Jul 20, 2021·Journal of Alzheimer's Disease : JAD·Caroline Bitencourt SoaresPâmela Billig Mello-Carpes

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