Oxidative stress and suicidal erythrocyte death

Antioxidants & Redox Signaling
Florian LangMichael Föller

Abstract

Eryptosis, the suicidal erythrocyte death, is characterized by cell shrinkage, membrane blebbing, and phosphatidylserine translocation to the outer membrane leaflet. Phosphatidylserine at the erythrocyte surface binds endothelial CXCL16/SR-PSOX (CXC-Motiv-Chemokin-16/Scavenger-receptor-for-phosphatidylserine-and-oxidized-low-density-lipoprotein) and fosters engulfment of affected erythrocytes by phagocytosing cells. Eryptosis serves to eliminate infected or defective erythrocytes, but excessive eryptosis may lead to anemia and may interfere with microcirculation. Clinical conditions with excessive eryptosis include diabetes, chronic renal failure, hemolytic uremic syndrome, sepsis, malaria, iron deficiency, sickle cell anemia, thalassemia, glucose 6-phosphate dehydrogenase deficiency, glutamate cysteine ligase modulator deficiency, and Wilson's disease. Eryptosis is triggered by a wide variety of xenobiotics and other injuries such as oxidative stress. Signaling of eryptosis includes prostaglandin E₂ formation with subsequent activation of Ca(2+)-permeable cation channels, Ca(2+) entry, activation of Ca(2+)-sensitive K(+) channels, and cell membrane scrambling, as well as phospholipase A2 stimulation with release of platelet-ac...Continue Reading

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Citations

Dec 3, 2014·Toxicology and Applied Pharmacology·Itzel-Citlalli Aguilar-DoradoJosé-Víctor Calderón-Salinas
May 28, 2015·Expert Opinion on Therapeutic Targets·Florian LangElisabeth Lang
Dec 24, 2014·Toxins·Kousi AlzoubiFlorian Lang
Oct 20, 2015·European Journal of Clinical Investigation·Philipp AttanasioFlorian Lang
Jan 19, 2016·Pesticide Biochemistry and Physiology·Arbace OfficiosoFlorian Lang
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Oct 18, 2020·Toxics·Soisungwan SatarugKenneth R Phelps

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