Oxidative stress and the pathogenesis of Parkinson's disease

Neurology
P Jenner, C W Olanow

Abstract

Current concepts of the pathogenesis of Parkinson's disease (PD) center on the formation of reactive oxygen species and the onset of oxidative stress leading to oxidative damage to substantia nigra pars compacta. Extensive postmortem studies have provided evidence to support the involvement of oxidative stress in the pathogenesis of PD; in particular, these include alterations in brain iron content, impaired mitochondrial function, alterations in the antioxidant protective systems (most notably superoxide dismutase [SOD] and reduced glutathione [GSH]), and evidence of oxidative damage to lipids, proteins, and DNA. Iron can induce oxidative stress, and intranigral injections have been shown to induce a model of progressive parkinsonism. A loss of GSH is associated with incidental Lewy body disease and may represent the earliest biochemical marker of nigral cell loss. GSH depletion alone may not result in damage to nigral neurons but may increase susceptibility to subsequent toxic or free radical exposure. The nature of the free radical species responsible for cell death in PD remains unknown, but there is evidence of involvement of hydroxyl radical (OH.), peroxynitrite, and nitric oxide. Indeed, OH. and peroxynitrite formation m...Continue Reading

Citations

Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·S AimeL Lopiano
Jun 17, 1998·Molecular Neurobiology·J Haavik, K Toska
Sep 21, 2004·Naunyn-Schmiedeberg's Archives of Pharmacology·Markus M ForsbergPekka T Männistö
Mar 24, 2005·Journal of Neural Transmission·K R KesslerG Auburger
Jun 1, 2006·Journal of Neural Transmission·M B H YoudimS Mandel
Feb 1, 2008·Journal of Neural Transmission·Hironori YokoyamaTsutomu Araki
Jan 4, 2012·Journal of Neural Transmission·Mahesh Ramalingam, Sung-Jin Kim
Apr 26, 2011·Cellular and Molecular Neurobiology·Graziela S RibasCarmen R Vargas
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Hui YangSheng-Di Chen
Oct 13, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jae-Kyung LeeMalú G Tansey
Feb 5, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Fabio Blandini
Sep 18, 2007·Journal of Molecular Neuroscience : MN·Anna MoszczynskaFang Liu
Feb 17, 2009·Journal of Molecular Neuroscience : MN·Pei RenJun-Xia Xie
Jul 28, 2011·Journal of Molecular Neuroscience : MN·Vincent RiesGünter U Höglinger
Mar 5, 2009·Molecular Neurobiology·Thomas S Guillot, Gary W Miller
Apr 28, 2005·Free Radical Biology & Medicine·Johannes Everse, Penelope W Coates
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·James StankiewiczRohit Bakshi
Feb 11, 2004·Progress in Biophysics and Molecular Biology·Matthew C Zimmerman, Robin L Davisson
Apr 14, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mark A TirmensteinLester W Schwartz
Nov 24, 1999·The American Journal of Medicine·P SaikumarM A Venkatachalam
Sep 15, 2000·Brain Research·P ShashidharanC W Olanow
Jan 14, 2003·European Journal of Pharmacology·Rebecka KlintenbergPer E Andrén
Jul 16, 2003·European Journal of Pharmacology·Paul AounJames W Simpkins
Jul 16, 2003·European Journal of Pharmacology·M Francisca Molina-JimenezJuana Benedi
Jul 25, 2003·European Journal of Pharmacology·Xiao-Chun ChenChao-Hui Zhao

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