Oxidative stress and vascular disease in diabetes: is the dichotomization of insulin signaling still valid?

Free Radical Biology & Medicine
Angelo AvogaroGian Paolo Fadini

Abstract

The current wisdom indicates that insulin's positive effects, normoglycemia, vasodilation, and anti-inflammation, are mediated by the canonical phosphoinositide 3-kinase (PI3K)/Akt pathway whereas the negative effects are mediated by the mitogen-activated protein kinase (MAPK)/extracellular regulated kinase (ERK) pathway. Much of the intracellular oxidant stress is mediated by the MAPK/ERK pathway which is a downstream signal also for other proatherogenic hormones such as angiotensin II. However, recent evidence links MAPK activation to antioxidant activity and vascular protection. We argue against a dichotomization of insulin signaling also in light of the concept that ERK-MAPK represents a critical node in the intracellular insulin network responsible for several positive effects related not only to vascular function but also to life span.

References

Nov 16, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shizuo IkeyamaNikki J Holbrook
Jan 25, 2003·Science·Matthias BlüherC Ronald Kahn
Feb 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Claudio NapoliPierGiuseppe Pelicci
Dec 5, 2003·Archives of Biochemistry and Biophysics·Nándor MarczinMagdi Yacoub
Dec 6, 2003·Science·Morris F White
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·James P McClungXin Gen Lei
Jul 6, 2004·The American Journal of Medicine·Willa A HsuehManuel J Quiñones
Sep 1, 2004·Mechanisms of Ageing and Development·Cosimo TortorellaSalvatore Antonaci
Dec 14, 2004·Current Biology : CB·Tracey L Fisher, Morris F White
Mar 1, 2005·Cell·Thomas B L Kirkwood
Mar 15, 2005·Endothelium : Journal of Endothelial Cell Research·Masanori KanemuraYasufumi Sato
May 3, 2005·Journal of the American College of Cardiology·Gian Paolo FadiniAngelo Avogaro
May 27, 2005·Annals of the New York Academy of Sciences·Calogero CarusoClaudio Franceschi
Jul 7, 2005·Antioxidants & Redox Signaling·Barry J GoldsteinHiroyuki Motoshima
Aug 30, 2005·Experimental Gerontology·Nora Klöting, Matthias Blüher
Jan 18, 2006·Free Radical Biology & Medicine·Desmond JayKathy K Griendling
Jun 8, 2006·Cardiovascular Research·Yu-Jing GaoRobert M K W Lee
Aug 10, 2006·Free Radical Biology & Medicine·John S KimErik J Henriksen
Sep 5, 2006·Experimental Cell Research·Stephanie CarnesecchiIldiko Szanto
Feb 6, 2007·Diabetes Care·Gian Paolo FadiniAngelo Avogaro
Mar 31, 2007·Seminars in Thoracic and Cardiovascular Surgery·Paresh DandonaPriya Mohanty
May 15, 2007·Oncogene·A G TurjanskiJ S Gutkind
May 26, 2007·Endocrine Reviews·Ranganath MuniyappaMichael J Quon
Jul 4, 2007·Atherosclerosis·Gian Paolo FadiniMarcello Rattazzi
Jul 21, 2007·Science·Akiko TaguchiMorris F White
Aug 9, 2007·Nature Reviews. Molecular Cell Biology·Steven J Russell, C Ronald Kahn

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Citations

Jul 20, 2012·Journal of Agricultural and Food Chemistry·Wei-Yun ZhangChang-Seon Myung
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Nektarios Barabutis, Andrew V Schally
Feb 3, 2009·Metabolic Syndrome and Related Disorders·Gian Paolo FadiniAngelo Avogaro
Jul 2, 2010·Diabetes, Obesity & Metabolism·G P Fadini, A Avogaro
Jun 22, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Vinit N VaruMelina R Kibbe
Jan 5, 2011·Journal of Biomedicine & Biotechnology·Saliha Durmuş TekirKutlu Ö Ülgen
May 9, 2009·Circulation Research·David J R Fulton
Oct 17, 2012·Cardiovascular Diabetology·Manuela AragnoGiampiero Muccioli
Sep 17, 2009·Pflügers Archiv : European journal of physiology·Angelo AvogaroGian Paolo Fadini
Aug 19, 2009·Archives of Physiology and Biochemistry·Giovanni AnfossiMariella Trovati
Apr 24, 2013·The Journal of Surgical Research·Monica P RodriguezMelina R Kibbe
Feb 2, 2013·Vascular Pharmacology·Mattia AlbieroGian Paolo Fadini
Sep 1, 2011·Molecular and Cellular Endocrinology·Xin WangChun X Hai
Dec 12, 2012·Atherosclerosis·Gian Paolo Fadini
May 17, 2011·Vascular and Endovascular Surgery·Zachary M Emond, Melina R Kibbe
Mar 17, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yang LeeMariappan Muthuchamy
Apr 11, 2012·BioFactors·Lisa MenegazzoGian Paolo Fadini
Jun 4, 2016·Molecular Biology Reports·Xin Wang, Chunxu Hai
Jul 2, 2017·Clinical Science·John J Reho, Kamal Rahmouni
May 14, 2016·Molecular Medicine Reports·Yue-E DaiQian-Qi Liu
May 28, 2020·American Journal of Physiology. Endocrinology and Metabolism·Emmanouil KorakasVaia Lambadiari
Sep 15, 2020·Frontiers in Endocrinology·Karina Colombera PeresLucas Leite Cunha

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