Oxidative stress, antioxidant capacity, biomolecule damage, and inflammation symptoms of sickle cell disease in children

Hematology
Sebaranjan BiswalArttatrana Pal

Abstract

The phenotypic expression of sickle cell disease (SCD) is a complex pathophysiologic condition. However, sickle erythrocytes might be the cause for multiple sources of pro-oxidant processes with consequent linked to chronic and systemic oxidative stress. Herein, we explored the SCD phenomena could be the result in formation of oxidative stress as well as inflammation in children. Blood samples of 147 SCD subjects were evaluated. A control group was formed of 156 individuals without SCD. Different oxidative stress markers and inflammatory mediators were measured by using various biochemical techniques. Plasma samples were collected from blood for the measurement of antioxidants and reactive oxygen species (ROS). The levels of plasma hydroxyl radical (HO•), and nitric oxide (NO) production were higher in SCD children in compared to control groups. The plasma antioxidants capacities such as superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx) and protein thiol levels were significantly reduced in SCD children. The plasma lipid peroxidation, protein carbonylation, DNA damage markers were significantly altered in different age groups of SCD children. Further, our results showed that SCD childre...Continue Reading

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Citations

Mar 12, 2019·Expert Review of Hematology·Bruno Deltreggia Benites, Sara Teresinha Olalla-Saad
Sep 12, 2019·Blood Advances·Atinuke M Dosunmu-OgunbiAdam C Straub
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Aug 22, 2021·International Journal of Biological Macromolecules·Mehrnaz EbrahimiAli Akbar Moosavi-Movahedi
Apr 29, 2020·Journal of the Neurological Sciences·Igor F DomingosAntonio R Lucena-Araujo
Dec 19, 2021·Anaesthesia Critical Care & Pain Medicine·Dominique Djomo TamchomLuc Van Obbergh

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