Oxidative stress as a cofactor in spinocerebellar ataxia type 2.

Redox Report : Communications in Free Radical Research
Mariela Guevara-GarcíaJulio César García-Rodríguez

Abstract

Spinocerebellar ataxia type 2 (SCA2) is a redox-sensitive neurodegenerative disease affecting the cerebellum, fibre connections in the cerebellum, the peripheral nervous system, and extracerebellar central pathways. Currently, Cuba has the highest reported global rate for this disease. The aim of this review article is to summarize and discuss the current knowledge about evidence of oxidative stress during SCA2. Recent reports have suggested that ataxin 2 and other related factors contribute to the redox imbalance in this disease. It is important to recognize and clarify the molecular mechanisms associated with the redox imbalance to consider ataxias innovative approaches to counteract oxidative stress-induced tissue damage, through alternative therapeutic or nutritional intervention in SCA2 and related diseases.

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Dec 31, 2014·Experimental Neurobiology·Edith Sturm, Nadia Stefanova
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