PMID: 18707586Aug 19, 2008Paper

Oxidative stress as regulatory factor for fatty-acid-induced uncoupling involving liver mitochondrial ADP/ATP and aspartate/glutamate antiporters of old rats

Biochemistry. Biokhimii︠a︡
V N Samartsev, O V Kozhina

Abstract

Palmitate-induced uncoupling, which involves ADP/ATP and aspartate/glutamate antiporters, has been studied in liver mitochondria of old rats (22-26 months) under conditions of lipid peroxidation and inhibition of oxidative stress by antioxidants--thiourea, Trolox, and ionol. It has been shown that in liver mitochondria of old rats in the absence of antioxidants and under conditions of overproduction of conjugated dienes, the protonophoric uncoupling activity of palmitate is not suppressed by either carboxyatractylate or aspartate used separately. However, the combination of carboxyatractylate and aspartate decreased uncoupling activity of palmitate by 81%. In this case, palmitate-induced uncoupling is limited by a stage insensitive to both carboxyatractylate and aspartate. In the presence of antioxidants, the palmitate-induced protonophoric uncoupling activity is suppressed by either carboxyatractylate or aspartate used separately. Under these conditions, palmitate-induced uncoupling is limited by a stage sensitive to carboxyatractylate (ADP/ATP antiporter) or aspartate (aspartate/glutamate antiporter). In the absence of antioxidants, the uncoupling activity of palmitate is not suppressed by ADP either in the absence or in the ...Continue Reading

References

Jun 1, 1991·The Journal of Clinical Investigation·G AmbrosioM Chiariello
Feb 1, 1991·Archives of Biochemistry and Biophysics·G Paradies, F M Ruggiero
Jul 1, 1989·European Journal of Biochemistry· Andreyev AYuT V Vygodina
Nov 15, 1981·The Biochemical Journal·W D SchwenkeH Sies
Apr 16, 1998·Biochimica Et Biophysica Acta·V P Skulachev
Aug 26, 1998·Biochimica Et Biophysica Acta·G Lenaz
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Jul 31, 2003·Journal of Bioenergetics and Biomembranes·Tatiana ArmeniMaurizio Battino
Aug 4, 2004·Experimental Gerontology·Sergey Kamzalov, Rajindar S Sohal
Aug 12, 2004·Free Radical Biology & Medicine·Martin D BrandNadeene Parker
Jan 12, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sharon JudgeChristiaan Leeuwenburgh
Apr 6, 2005·Biochemistry. Biokhimii︠a︡·E N Mokhova, L S Khailova
Apr 6, 2005·Biochemistry. Biokhimii︠a︡·A Yu AndreyevA A Starkov
Mar 15, 2006·Apoptosis : an International Journal on Programmed Cell Death·V P Skulachev

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Citations

May 4, 2010·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·V N SamartsevS R Rybakova

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