Oxidative stress, biochemical, lipid peroxidation, and antioxidant responses in Clarias gariepinus exposed to acute concentrations of ivermectin

Environmental Science and Pollution Research International
Emmanuel Okechukwu OguejiFriday Nweke

Abstract

The short-term effects of ivermectin (IVMT) on the oxidative stress and biochemical parameters of Clarias gariepinus juvenile was assessed under semi-static conditions at concentrations of 9 to 25 μg L-1 for up to 4 days. Juveniles were highly sensitive to ivermectin, with an LC50 of 15 μg L-1.The antioxidant enzyme profile assessed included glutathione reductase (GR), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT). General stress biomarkers such as serum glucose, protein, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were also determined at 24-h, 48-h, 72-h, and 96-h exposure durations. Lipid peroxidation showed significant (p < 0.05) decreases in higher concentrations (21 μg L-1and 25 μg L-1) and durations of exposure (72 h and 96 h). Significant concentration-dependent increases (p < 0.05) were recorded in the liver function enzymes, superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GR) when compared to the control. GPx decreased significantly (p < 0.05) in higher concentrations (21 μg L-1and 25 μg L-1) and durations of exposure (48-96 h). Protein showed significant concentration-dependent decreases, while glucose recorded a...Continue Reading

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Citations

Aug 20, 2020·Environmental Science and Pollution Research International·Christopher Didigwu NwaniJosephine Chinenye Madu
Feb 9, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ritwick BhattacharyaNimai Chandra Saha
Jun 6, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Temitope Dadewura MelefaChristopher D Nwani
Nov 8, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Malachy N O AjimaPramod K Pandey
Apr 16, 2021·Environmental Science and Pollution Research International·Malachy N O AjimaPramod K Pandey
Jun 15, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Temitope Dadewura Melefa, Christopher Didigwu Nwani
Nov 4, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jasmine SinghaPrasanna Kumar Patil

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