Oxidative stress biomarkers in long-term participants in clean-up work after the Hebei Spirit oil spill

The Science of the Total Environment
Su Ryeon NohDomyung Paek

Abstract

The oil tanker Hebei Spirit spilled 12,547kL of oil near the western coastline of Korea on December 7, 2007. We aimed to investigate the relationship between oil spill exposure and oxidative stress in residents living near the affected area. Study subjects were 671 residents who participated in a health examination between February and September 2009. As surrogates for oil spill exposure, we used the total duration of clean-up work and levels of urinary metabolites of polycyclic aromatic hydrocarbons (PAHs), 1-hydroxypyrene (1-OHP) and 2-naphthol (2-NAPH). Oxidative stress was measured using urinary levels of malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), indicators of lipid peroxidation and oxidative DNA damage, respectively. Levels of oxidative stress biomarkers were significantly increased with longer involvement in clean-up work over one year after the Hebei Spirit oil spill (MDA, p-trend<0.0001; 8-OHdG, p-trend<0.0001). As more time elapsed since the last involvement in clean-up, the total duration of clean-up work participation and levels of PAH metabolites (1-OHP and 2-NAPH), as well as levels of the oxidative stress biomarkers (MDA and 8-OHdG) decreased further. The level of 1-OHP had a significant posi...Continue Reading

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