PMID: 9163781May 1, 1997Paper

Oxidative stress changes in L-arginine-induced pancreatitis in rats

Pancreas
Ilona S VargaM Sasvari

Abstract

The important role of oxygen radicals in acute experimental pancreatitis was demonstrated by study of the changes in the antioxidant system in the blood, liver, kidney, and pancreas of rats after the administration of a large quantity of L-arginine (L-Arg). The changes in lipid peroxidation and in reduced and oxidized glutathione were followed, as well as the activities of peroxide-decomposing enzymes (glutathione peroxidase and catalase) and H2O2-producing superoxide dismutases. The results demonstrated that "oxidative stress" develops and acute pancreatitis appears rapidly after L-Arg treatment. Oxidative stress symptoms are expressed 24 h after the final treatment. Slow restitution of the studied antioxidant system can be demonstrated as early as after 48 h.

Citations

Mar 14, 2003·Free Radical Biology & Medicine·Zoltán RakonczayTamás Takács
Jan 7, 2004·Pancreas·Carmen Sánchez-BernalNieves Pérez-González
Nov 22, 2013·World Journal of Gastroenterology : WJG·Jing-Bo ZhaoThomas Dahl Nissen
Dec 25, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Balázs KuiZoltán Rakonczay
Nov 17, 2010·Experimental Lung Research·Alison S F ElderDani-Louise Dixon
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Kim Hue SuChristopher Christophi
Apr 28, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Hayam AteyyaNagla A El-Sherbeeny
Jan 18, 2011·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·D Karthik, S Ravikumar
Apr 1, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Constanze H KubischCraig D Logsdon
Jul 9, 2004·World Journal of Gastroenterology : WJG·Péter HegyiLászló Czakó
Feb 17, 2006·World Journal of Gastroenterology : WJG·Annamaria SzabolcsTamas Takacs
Jun 25, 2005·Arquivos De Gastroenterologia·Odery RamosSérgio Gabriel da Silva Barros

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