Oxidative stress during peritoneal dialysis: implications in functional and structural changes in the membrane

Kidney International
H NohHi Bahl Lee

Abstract

Progressive peritoneal fibrosis, membrane hyperpermeability, and ultrafiltration failure have been observed in patients on long-term peritoneal dialysis (PD). The present study tested the hypothesis that reactive oxygen species (ROS) generated by conventional PD solution (PDS) mediate functional and structural alterations of peritoneal membrane in vivo. Sprague-Dawley rats were randomized to control, PDS, PDS with an antioxidant, and PDS with an angiotensin II (Ang II) receptor blocker. Commercial PDS containing 3.86% glucose (20-30 ml) with or without N-acetylcystein (NAC) 10 mM or losartan 5 mg/kg was administered intraperitoneally twice a day for 12 weeks. Control rats received sham injection. Rats treated with PDS had significantly lower drain volume and D(4)/D(0) glucose, but higher D(4)/P(4) creatinine and increased membrane thickness and endothelial NOS (eNOS) expression compared to control rats. Omental transforming growth factor (TGF)-beta1, vascular endothelial growth factor (VEGF), collagen I, and heat-shock protein (hsp) 47 expression and lipid peroxide levels and dialysate VEGF and Ang II concentrations were significantly increased in rats treated with PDS compared to control. All of these changes were prevented by...Continue Reading

References

Nov 10, 1994·The New England Journal of Medicine·W A Border, N A Noble
Mar 1, 1993·Journal of the American Society of Nephrology : JASN·G Wolf, E G Neilson
Sep 1, 1995·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·P Kubes
Sep 18, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B C Kone
Jun 17, 1998·The Journal of Clinical Investigation·T MuroharaJ M Isner
May 8, 1999·Free Radical Biology & Medicine·H HaK H Kim
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P GreenwelM Rojkind
Mar 17, 2000·Circulation Research·K K GriendlingM Ushio-Fukai
Feb 15, 2001·The Journal of Laboratory and Clinical Medicine·M M ZweersR T Krediet
Apr 24, 2001·Journal of the American Society of Nephrology : JASN·Simon J DaviesGavin I Russell
May 9, 2001·Current Opinion in Nephrology and Hypertension·M Ruiz-OrtegaJ Egido
Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Peter J MargettsJack Gauldie
Sep 22, 2001·Hypertension·S A MezzanoJ Egido
Jan 24, 2002·Journal of the American Society of Nephrology : JASN·John D WilliamsGeraint T Williams
Feb 1, 2003·The Journal of Biological Chemistry·Jian-Mei Li, Ajay M Shah
Mar 28, 2003·Nephron. Physiology·Ki-Hwan HanJin Kim
Aug 26, 2004·Kidney International·Siska MortierAn S De Vriese
Dec 2, 2004·American Journal of Physiology. Renal Physiology·Ki-Hwan HanJin Kim
Dec 14, 2004·Journal of the American Society of Nephrology : JASN·Peter J MargettsMargaret M Kelly

❮ Previous
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Citations

Jul 20, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Andreas Fusshoeller
May 8, 2010·International Urology and Nephrology·Tom Cornelis, Dimitrios G Oreopoulos
Feb 22, 2012·Nature Reviews. Nephrology·Elvia García-LópezSimon Davies
Apr 30, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sheron LatchaJoseph Mattana
Jan 8, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hung-Tien KuoHung-Chun Chen
Jun 30, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maurizio BruschiEnrico Verrina
Mar 14, 2008·American Journal of Nephrology·Naomi FukuokaHirofumi Makino
Apr 23, 2011·Journal of the American Society of Nephrology : JASN·Lars P KihmVedat Schwenger
Aug 28, 2010·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Joo Young HuhHunjoo Ha
Nov 6, 2012·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Hideki YokoiKazuwa Nakao
Mar 9, 2013·Journal of the American Society of Nephrology : JASN·Dagmara Borzych-DuzalkaUNKNOWN International Pediatric Peritoneal Dialysis Network (IPPN) Registry
Mar 29, 2011·Seminars in Nephrology·Catriona Goodlad, Edwina A Brown
Oct 21, 2015·Kidney Research and Clinical Practice·Mina YuDuk-Hee Kang
Dec 17, 2008·European Journal of Pharmacology·Stefania MondelloSalvatore Cuzzocrea
Sep 1, 2015·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Shigehisa AokiShuji Toda
Aug 19, 2015·Journal of Clinical Pharmacy and Therapeutics·P Ditsawanon, P Aramwit
Oct 26, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiyeon KoDuk-Hee Kang
Dec 29, 2007·Journal of Korean Medical Science·Hi Bahl Lee, Hunjoo Ha
May 21, 2013·Molecular Medicine Reports·Jing XiaoZhang-Suo Liu
Oct 9, 2014·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Keiichi WakabayashiYasuhiko Tomino
Jan 9, 2010·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Eun-Young SeoHunjoo Ha
Sep 15, 2020·European Journal of Immunology·Alexandra HelmkeSibylle von Vietinghoff
Oct 2, 2019·Indian Journal of Nephrology·Natalia StepanovaOlena Burdeyna
Feb 19, 2019·Oxidative Medicine and Cellular Longevity·Vassilios LiakopoulosEvangelia Dounousi
May 12, 2018·Oxidative Medicine and Cellular Longevity·Vassilios LiakopoulosPeter R Mertens

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