PMID: 7895229Jan 1, 1995

Oxidative stress during reperfusion of human hearts: potential sources of oxygen free radicals

Cardiovascular Research
S CurelloF Messineo


The aim was to examine the role of neutrophil activation in the genesis of oxidative stress during the early phases of reperfusion after ischaemia in patients subjected to aortocoronary bypass grafting. Ten selected patients were studied. All had normal ejection fraction and normal left ventricular end diastolic pressures before operation. Each patient required at least three grafts, so that the duration of aortic crossclamping exceeded 30 min, the minimum ischaemic period required to detect oxidative stress upon reperfusion. Oxidative stress was assessed by measuring the formation and release of oxidised glutathione (GSSG) in the coronary sinus 1 min before and 3 min after the start of the cardiopulmonary bypass, and then 1, 5, 10, and 20 min after removal of the aortic clamp, and again 5 and 10 min after the end of the cardiopulmonary bypass. The arterial-coronary sinus difference for neutrophils, elastase-alpha 1 protease complex (elastase), and creatine phosphokinase was also monitored at the same intervals. Before clamping GSSG was undetectable in arterial and coronary sinus blood. There was no significant arterial-coronary sinus difference for neutrophils or elastase [53(SEM 66) and 1.10(2.49) micrograms.litre-1...Continue Reading


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Related Concepts

Coronary Artery Bypass Surgery
Macro-Creatine Kinase
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Neutrophil Band Cells
Elastase I
Myocardial Reperfusion Injury
Myocardial Ischemia
Reactive Oxygen Species

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