PMID: 20623871Jul 14, 2010Paper

Oxidative stress effects and damage of nanoscale TiO2 and ZnO on zebrafish

Huan jing ke xue= Huanjing kexue
Dao-wen XiongWen-tao Zhu

Abstract

The oxidative stress effects and damage of nanoscale zinc oxide (nZnO), titanium dioxide (nTiO2) and their bulk counterparts (i.e., ZnO/bulk, TiO2/bulk) suspension on gill, intestine and liver of zebrafish (Danio rerio) were studied, as well as the characterization of nZnO, nTiO2 ZnO/bulk and TiO2/bulk and the amount of .OH in suspension in the presence of light were studied. The results show that the size distribution of nanoparticle and bulky particle are similar in suspension, while the amount of SOH in 50 mg/L nTiO2, nZnO suspension are 2.17 mmol/L, 0.72 mmol/L respectively in the presence of 96 h illumination, which is much higher than that of 50 mg/L bulky particle suspension (not detected). As exposed to 50 mg/L nTiO2 suspension, in contrast to control, the superoxide dismutase (SOD), catalase(CAT) and reduced glutathione (GSH), protein carbonyl content in liver tissue of zebrafish are 70.2%, 65.4%, 53%, 178.1% respectively, and the SOD activity and GSH, malondialdehyde (MDA) content in digestive tract are 149.6%, 212.9% and 217.2% respectively. The MDA content in gill is 160.9% than that of control as exposed to 50 mg/L nTiO2 suspension. However, there are no toxic effects on zebrafish after 96 h exposure to 50 mg/L TiO...Continue Reading

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