Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases

The FEBS Journal
Rosi BissingerFlorian Lang

Abstract

The average lifespan of circulating erythrocytes usually exceeds hundred days. Prior to that, however, erythrocytes may be exposed to oxidative stress in the circulation which could cause injury and trigger their suicidal death or eryptosis. Oxidative stress activates Ca2+ -permeable nonselective cation channels in the cell membrane, thus, stimulating Ca2+ entry and subsequent cell membrane scrambling resulting in phosphatidylserine exposure and activation of Ca2+ -sensitive K+ channels leading to K+ exit, hyperpolarization, Cl- exit, and ultimately cell shrinkage due to loss of KCl and osmotically driven water. While the mechanistic link between oxidative stress and anemia remains ill-defined, several diseases such as diabetes, hepatic failure, malignancy, chronic kidney disease and inflammation have been identified to display both increased oxidative stress as well as eryptosis. Recent compelling evidence suggests that oxidative stress is an important perpetrator in accelerating erythrocyte loss in different systemic conditions and an underlying mechanism for anemia associated with these pathological states. In the present review, we discuss the role of oxidative stress in reducing erythrocyte survival and provide novel insig...Continue Reading

References

Feb 1, 1977·Annals of Internal Medicine·D R Budman, A D Steinberg
Apr 1, 1990·British Medical Bulletin·E A Fagan, R Williams
Mar 1, 1990·British Journal of Haematology·H IdeguchiN Hamasaki
Mar 1, 1986·Annals of Internal Medicine·L B SeeffS B Benjamin
Sep 1, 1970·Annals of Internal Medicine·A DeissG E Cartwright
Jan 1, 1980·American Journal of Hematology·S J FormanP Hochstein
Mar 1, 1995·Arthritis and Rheumatism·L M WeissC A Agudelo
Jan 1, 1994·Kidney International·I IchikawaT Yoshioka
Oct 1, 1993·Molecular and Biochemical Parasitology·H Atamna, H Ginsburg
Jan 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·H HenningsS H Yuspa
Aug 6, 1999·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K AlamA M Al-Bekairi
Aug 24, 1999·Cell Calcium·L A WoonB D Roufogalis
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·B S Das, N K Nanda
Oct 8, 1999·Journal of the National Cancer Institute·J E Groopman, L M Itri
May 4, 2000·The American Journal of Pathology·C D CollardG L Stahl
Jun 23, 2000·Annals of the New York Academy of Sciences·M AslanB A Freeman
Jan 3, 2001·Free Radical Biology & Medicine·J PourahmadP J O'Brien
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Mar 19, 2002·The Journal of Physiology·Christophe DurantonFlorian Lang
Aug 20, 2002·The Oncologist·Michael S Gordon
Oct 9, 2002·Biochemistry·Kitty de JongFrans A Kuypers
Nov 20, 2002·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Karl S LangThomas Wieder
Nov 21, 2002·Cellular and Molecular Life Sciences : CMLS·P V Vignais
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jan 11, 2003·Blood·Susanne LudwiczekGünter Weiss
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·A C MaritimJ B Watkins
Mar 22, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D CellaJ Glaspy
Apr 3, 2003·Nature Reviews. Cancer·S Perwez HussainCurtis C Harris
Apr 18, 2003·Cell Death and Differentiation·K S LangS M Huber
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Svetlana MyssinaFlorian Lang
Nov 6, 2003·American Journal of Physiology. Cell Physiology·Philipp A LangStephan M Huber

❮ Previous
Next ❯

Citations

Jul 8, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Madeline FinkFlorian Lang
Aug 21, 2019·Journal of Environmental and Public Health·Valeria C Morales-AncajimaGustavo F Gonzales
Jun 12, 2020·Molecular Biology Reports·Jibin LiuFlorian Lang
Apr 2, 2020·Frontiers in Immunology·Elie NaderPhilippe Connes
Mar 19, 2020·Current Alzheimer Research·Chien-Tai HongLi-Nien Chien
Aug 23, 2020·Antioxidants·Alina Podkowińska, Dorota Formanowicz
Jul 1, 2020·International Journal of Molecular Sciences·Paulina SicińskaBożena Bukowska
Sep 22, 2018·Apoptosis : an International Journal on Programmed Cell Death·Rosi BissingerFlorian Lang
Apr 18, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Carlos J MunozPedro Cabrales
Dec 29, 2020·Toxicology and Applied Pharmacology·Solomon E OwumiOyeronke A Odunola
Feb 10, 2021·Journal of Cellular Physiology·Alessia RemiganteAngela Marino
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Gabriela Ferreira DiasPeter Kotanko
Feb 4, 2021·Nutrients·Giulio VernaPietro Campiglia
Mar 18, 2021·Journal of Diabetes Research·Yaqi WangYan Su
Jun 9, 2020·Biochemical and Biophysical Research Communications·S N BalajiVishal Trivedi
Mar 30, 2021·Kidney International Supplements·Peter A McCullough
Mar 19, 2019·Toxicology and Applied Pharmacology·Mohammad A AlfhiliMyon-Hee Lee
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Valeria PasciuFiammetta Berlinguer
Jul 3, 2021·Journal of Clinical Medicine·Sadayuki ItoShiro Imagama
Jun 1, 2019·Biochimica Et Biophysica Acta. Biomembranes·Vette Martínez-VieyraDoris Cerecedo
Dec 4, 2021·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Julia LieserNatali Bauer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Karl S LangFlorian Lang
Antioxidants & Redox Signaling
Florian LangThomas Wieder
Basic & Clinical Pharmacology & Toxicology
Rosi BissingerFlorian Lang
Annals of Hematology
Sergios GatidisFlorian Lang
© 2022 Meta ULC. All rights reserved