Oxidative stress, Helicobacter pylori, and OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms in a Turkish population with colorectal carcinoma

Genetic Testing and Molecular Biomarkers
Ayse Basak EnginAli Esat Karakaya

Abstract

The contribution of polymorphisms of DNA repair genes OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln in developing colorectal carcinoma is controversial. Whether the group 1A carcinogen Helicobacter pylori is a risk factor or not in these patients could not be clearly elucidated. One hundred ten colorectal cancer patients and 116 cancer-free individuals constituted the test and control groups, respectively. The association of OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms and the susceptibility to colorectal carcinoma with or without oxidative stress were evaluated. DNA was extracted from peripheral blood cells and genotypes were determined using polymerase chain reaction-restriction fragment length polymorphism. For serum nitric oxide and total antioxidant status assay, spectrophotometric analyses were used. Serum albumin measurements were performed using an autoanalyzer. H. pylori IgG was measured by ELISA. The serum albumin concentrations of cancer patients were significantly lower than those of the controls (p < 0.05). The carriers of the variant genotype of OGG1 (odds ratio: 0.963; 95% confidence interval: 0.446-2.079), XPC (0.789, 0.366-1.700), or XPD (0.532, 0.259-1.094) did not associate with the incre...Continue Reading

References

Nov 1, 1983·JPEN. Journal of Parenteral and Enteral Nutrition·D S McLaren, M M Meguid
Apr 17, 1998·Cancer Metastasis Reviews·L L Thomsen, D W Miles
Jan 16, 1999·Journal of the National Cancer Institute·S AmbsC C Harris
Feb 17, 2001·Nitric Oxide : Biology and Chemistry·K M MirandaD A Wink
Mar 21, 2001·Apoptosis : an International Journal on Programmed Cell Death·H U SimonF Levi-Schaffer
Jul 27, 2001·Carcinogenesis·K HemminkiS M Hou
Sep 13, 2001·Alimentary Pharmacology & Therapeutics·D A Israel, R M Peek
Jan 5, 2002·The American Journal of Gastroenterology·H ShmuelyJ Yahav
Sep 18, 2002·Gut·B Leggett
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Shanthi Adimoolam, James M Ford
Apr 30, 2003·World Journal of Gastroenterology : WJG·Jae-Il KimSeok-Hyo Chang
Apr 20, 2004·Critical Care Medicine·Gregory J QuinlanTimothy W Evans
Dec 24, 2004·American Journal of Epidemiology·Simone Benhamou, Alain Sarasin
Mar 31, 2005·Trends in Immunology·Cosima T BaldariJohn L Telford
Oct 12, 2005·International Journal of Cancer. Journal International Du Cancer·Julie E GoodmanCurtis C Harris
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Victor MorenoFederico Canzian
Jun 14, 2006·Mutation Research·Maria Teresa RussoMargherita Bignami
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sonja I BerndtKathy J Helzlsouer
Jul 20, 2007·Experimental Eye Research·Mustafa UnalKazim Devranoğlu
May 29, 2008·International Journal of Colorectal Disease·Ya-Shuang ZhaoDing-Yun You

❮ Previous
Next ❯

Citations

Jan 30, 2013·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Xia JiangKun Chen
Apr 28, 2011·Acta Crystallographica. Section E, Structure Reports Online·Hoong-Kun FunBoja Poojary
Dec 4, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Min LuJiannan Zhang
Feb 21, 2014·Genetic Testing and Molecular Biomarkers·Cheng ChenShiwei Duan
Aug 27, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuantao SuJiangfan Zhu
May 13, 2011·Current Medical Research and Opinion·Emel CanbayDursun Bugra
Feb 13, 2013·International Journal of Cancer. Journal International Du Cancer·Jing HeQing-Yi Wei
May 16, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Q WuD-M Fan
May 23, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F WangZ S Lv
Oct 18, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yang WangXiubao Ren
Jun 20, 2015·Disease Markers·Kashif AliMahmood Akhtar Kayani
Nov 14, 2014·Molecular Biology Reports·Katarzyna Paszkowska-SzczurTadeusz Dębniak
Sep 18, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mingli Zhang, Runyang Mo
Oct 20, 2012·Toxicology and Industrial Health·Bensu KarahalilErdem Coşkun
Apr 4, 2015·World Journal of Gastroenterology : WJG·Ayse Basak EnginAtilla Engin
Oct 2, 2012·Human & Experimental Toxicology·B KarahalilD M Wilson
May 18, 2016·World Journal of Gastroenterology : WJG·Ying QingTeng-Fei Yin
Dec 28, 2019·Experimental and Molecular Pathology·Fawaz N Al-ShaheriNehad M Ayoub

❮ Previous
Next ❯

Methods Mentioned

BETA
blood
ELISA
genotyping
PCR
electrophoresis

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.