Oxidative stress in a model for experimental diabetic retinopathy: treatment with antioxidants

Archivos de la Sociedad Española de Oftalmología
M MirandaFrancisco J Romero

Abstract

Diabetic retinopathy is the primary cause of blindness in developed countries, and though strict glycemic control is desirable to prevent complications, this is not always achievable. Thus, adjunctive therapies are needed to help in preventing or delaying the onset of diabetic complications. We have studied the biochemical and functional changes in the retina of diabetic mice, and the ability of ebselen and lutein, two antioxidants, to reverse these effects, using as a comparison the effect of insulin therapy. Alloxan injection was used to achieve hyperglycemia. Malondialdehyde (MDA) concentration in blood and glutathione peroxidase (GPx) activity in eye homogenate were measured. Serial electroretinograms (ERG) were recorded. MDA concentration in the blood was high in diabetic animals. GPx activity in eye homogenate decreased in the diabetic conditions. Maximal electroretinogram amplitude decreased in diabetic animals with respect to controls. Ebselen and lutein restored MDA levels, GPx activity and ERG amplitude, and had no effect on glycemia. These results call for further studies on ebselen or lutein as adequate adjunctive therapies for diabetes.

Citations

Jul 9, 2008·Free Radical Research·Siv Johnsen-SorianoFrancisco Javier Romero
Dec 3, 2008·Journal of Physiology and Biochemistry·M MuriachF J Romero
Sep 14, 2007·Ophthalmic Research·M MirandaF J Romero
Apr 15, 2005·Journal of Dairy Science·S T JonesJ N Losso
Nov 24, 2020·Future Medicinal Chemistry·Jun WangLili Zou
Aug 29, 2006·Free Radical Biology & Medicine·María MuriachMaría Miranda
Sep 13, 2006·Chemico-biological Interactions·N B V BarbosaC W Nogueira
Sep 18, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N B V BarbosaC W Nogueira
Oct 30, 2007·Free Radical Biology & Medicine·María MirandaFrancisco Bosch-Morell

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