Oxidative Stress in Aortas of Patients with Advanced Occlusive and Aneurysmal Diseases

Annals of Vascular Surgery
Márcio Luís LucasClaudio G Zettler

Abstract

Aortoiliac occlusive disease (AOD) and abdominal aortic aneurysm (AAA) are very important cardiovascular diseases that present different aspects of pathophysiology; however, oxidative stress and inflammatory response seem be relevant in both of them. Our objective was to evaluate oxidative damage and degree of inflammatory infiltrate in aortas of patients surgically treated for AOD and AAA. Levels of reactive oxygen species (ROS), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, and myeloperoxidase (MPO) expression as well as nitrite levels and superoxide dismutase (SOD) and catalase (CAT) activities were evaluated in aortas of patients with AOD (n = 16) or AAA (n = 14), while the control group was formed by cadaveric organ donors (n = 10). We also analyzed the degree of inflammatory infiltrate in these aortas. There was an increase in ROS levels and NADPH oxidase activity in patients with AOD and AAA when compared with the control group, and the AOD group demonstrated higher ROS production and NADPH oxidase activity and also nitrite levels when compared with the AAA group (P < 0.001). On the other hand, an increase of SOD activity in the AOD group and CAT activity in the AAA group was observed. Inflammator...Continue Reading

Citations

Feb 15, 2019·Circulation Research·Raymundo Alain Quintana, W Robert Taylor
Aug 14, 2019·Journal of Cellular and Molecular Medicine·Fabian EmrichMichael P Fischbein
Sep 4, 2020·International Journal of Molecular Sciences·Rijan GurungVitaly Sorokin

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