PMID: 15379416Sep 24, 2004Paper

Oxidative stress in childhood obesity

Journal of Pediatric Endocrinology & Metabolism : JPEM
Mehmet Emre AtabekIbrahim Erkul

Abstract

To measure products of free radical damage in childhood obesity. Plasma free radicals were assayed in 24 children with exogenous obesity and 24 non-obese healthy controls. A new colorimetric method was used that measures the generation of peroxy radicals (D-Roms), first products of the reaction between free radicals and oxygen. D-Roms levels were higher in the obese children than in the non-obese group (33.3+/-10.1 mg% of H2O2 vs 22.8+/-2.8 mg% of H2O2; p <0.001). Moreover, D-Roms levels were higher in children with hyperlipidemia than in children with normolipidemia (49.6+/-3.1 mg% of H2O2 vs 27.8+/-3.2 mg% of H2O2; p <0.001). D-Roms level was positively correlated with waist-hip ratio, serum total cholesterol, serum triglycerides, serum low-density lipoprotein-cholesterol, systolic blood pressure, diastolic blood pressure and fasting blood glucose in obese children. In a multivariate regression model for obese children, the independent correlates for D-Roms level were systolic blood pressure (p <0.001) and serum total cholesterol (p <0.001), with the total variance explained being 82%. Our study demonstrates for the first time that there was increased D-Roms levels in obese children and adolescents and suggests that increased...Continue Reading

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Citations

May 11, 2013·Environmental Health and Preventive Medicine·Terumi Kogawa, Ikuo Kashiwakura
Jun 17, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshiki FukuiYouichi Abe
Aug 13, 2010·The Review of Diabetic Studies : RDS·Dario PitoccoGiovanni Ghirlanda
May 20, 2006·European Journal of Pediatrics·M Emre AtabekSelim Kurtoglu
Nov 9, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Pilar Codoñer-FranchEulalia Alonso-Iglesias
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal
May 27, 2008·Clinical Biochemistry·Malgorzata Krzystek-KorpackaAnna Noczynska
Nov 29, 2013·Clinical Physiology and Functional Imaging·Lewan ParkerAnthony S Leicht
Jun 23, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A J G WirixJ E Kist-van Holthe
Apr 29, 2015·Clinical Therapeutics·Toshiki FukuiYouichi Abe
Mar 1, 2011·Korean journal of family medicine·Young-Gyu ChoYang-Im Hur
Dec 30, 2016·Journal of Developmental Origins of Health and Disease·V TranN Holland
Aug 21, 2008·The Journal of Clinical Endocrinology and Metabolism·Dalal AlkazemiStan Kubow
May 23, 2017·Frontiers in Endocrinology·Lewan ParkerItamar Levinger
May 22, 2008·The Journal of Nutrition·Michael B Zemel, Xiaocun Sun
Feb 6, 2021·Scientific Reports·Dalal AlkazemiBanan Habra
Jan 22, 2021·International Immunopharmacology·Morteza IzadiAmir Hosein Ghazale

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