Oxidative stress in children with neurocysticercosis

The Pediatric Infectious Disease Journal
Rajniti PrasadTej B Singh

Abstract

Free radicals can cause neuronal injury and play an important role in pathogenesis of neurocysticercosis. This study was done to evaluate oxidative stress (antioxidants and oxidants) in cerebrospinal fluid (CSF) of children with neurocysticercosis and to observe their correlation with the type of seizure and outcome. Forty consecutive confirmed cases of neurocysticercosis were evaluated for their markers of reactive oxygen species, that is, oxidants (malondialdehyde, protein carbonyl and nitrite) and antioxidant (superoxide dismutase, glutathione peroxidase, ceruloplasmin, ascorbic acid, copper and zinc) concentrations in CSF. An equal number of children, age and sex matched with an idiopathic generalized tonic-clonic seizure, were studied as controls. Generalized tonic-clonic seizure (65%) was the most common presentation, and a single ring-enhancing lesion in the parietal lobe was the most common finding in cranial imaging. Oxidants such as malondialdehyde, protein carbonyl and nitrite in CSF were significantly elevated (P < 0.001), whereas antioxidants such as superoxide dismutase, glutathione peroxidase, ceruloplasmin, ascorbic acid, copper and zinc levels were significantly lower (P < 0.001) in children with neurocysticerc...Continue Reading

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Citations

Oct 4, 2015·Nutrition Reviews·Amene SaghazadehNima Rezaei
Jun 27, 2018·The American Journal of Tropical Medicine and Hygiene·Oscar H Del BruttoMark J Sedler
Mar 7, 2020·Journal of Clinical Medicine·Katarzyna Jezierska-WozniakWojciech Maksymowicz

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